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Study examines colonoscopy impact in older adults with borderline FIT values

Skip to content The CRC Digest Study examines colonoscopy impact in older adults with borderline FIT values Researchers used a regression discontinuity design to investigate whether CRC screening affects incidence among 2,773 adults aged 71-75 with FIT values between 80-120 ng/ml. (Int J Epidemiol) This content is informational

Salivary microbiome profiles distinguish early-onset CRC patients from healthy controls

Skip to content The CRC Digest Salivary microbiome profiles distinguish early-onset CRC patients from healthy controls Researchers collected saliva samples from 65 EOCRC patients and 63 controls, profiling the microbiota and developing screening models using machine learning algorithms. (BMC Microbiol) This content is informational only and does not constitute medical

CRC Research Finding

Skip to content The CRC Digest ♥ Dietary guidance during treatment linked to quality of life after cancer care A cross-sectional study of 610 cancer survivors (including 132 colorectal cancer patients) examined whether guidance on dietary habits or nutrition-related problems from healthcare professionals during treatment was associated with quality of life

Alabama study examines lifestyle and metabolic factors in early- vs late-onset CRC

Skip to content The CRC Digest Alabama study examines lifestyle and metabolic factors in early- vs late-onset CRC A retrospective study from 2010–2023 investigated whether associations between lifestyle factors (smoking, BMI) and clinical factors (type 2 diabetes, hypertension, hyperlipidemia) and age at CRC diagnosis differed by race. (Cancer Causes

Meta-analysis projects rising early-onset CRC burden through 2030

Skip to content The CRC Digest Meta-analysis projects rising early-onset CRC burden through 2030 A systematic review and meta-analysis evaluated early-onset colorectal cancer (diagnosed under age 50) incidence and temporal trends from 1990 to 2021, identifying associated risk factors and projecting burden through 2030. (Cureus) This content is informational only

CRC Research Update — July 17, 2026

Today's colorectal cancer research highlights

Precision oncology strategies beyond RAS and RAF in MSS colorectal cancer

Skip to content The CRC Digest Precision oncology strategies beyond RAS and RAF in MSS colorectal cancer Review outlines next-generation precision approaches for microsatellite-stable tumors, including antibody-drug conjugates, bispecific antibodies, DNA damage response targeting, and tumor microenvironment-directed therapies. (ESMO Open) This content is informational only and does not constitute medical

DR5/Ligase 3 feedback loop drives immunogenicity in dMMR/MSI CRC

Skip to content The CRC Digest DR5/Ligase 3 feedback loop drives immunogenicity in dMMR/MSI CRC Preclinical study investigated why dMMR/MSI colorectal cancers are intrinsically immunogenic and why some do not respond or develop resistance to immune checkpoint inhibitors. (Gastroenterology) This content is informational only and does not

CRC Research Finding

Skip to content The CRC Digest ◇ Review examines anti-VEGF plus checkpoint inhibitor combinations in GI cancers A narrative review synthesizes preclinical and clinical data on combining anti-VEGF agents with immune checkpoint inhibitors across gastrointestinal cancers, including colorectal cancer, with emphasis on optimal sequencing strategies. (Discov Oncol) This content is informational

CRC Research Update — July 16, 2026

Today's colorectal cancer research highlights