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Patient Navigation Boosts Colonoscopy Completion After Positive Stool Tests

Skip to content The CRC Digest ▪ SCREENING Patient Navigation Boosts Colonoscopy Completion After Positive Stool Tests A quality improvement initiative at Cleveland Clinic used patient navigators to contact adults aged 45–75 with positive stool-based tests who had not completed colonoscopy within 360 days, aiming for ≥80% completion within 6

Vactosertib Plus Pembrolizumab Shows Manageable Safety in Non-MSI-High mCRC

Skip to content The CRC Digest ◆ TRIAL DATA Vactosertib Plus Pembrolizumab Shows Manageable Safety in Non-MSI-High mCRC A phase Ib/IIa study of vactosertib combined with pembrolizumab in non-MSI-high metastatic colorectal cancer demonstrated a manageable safety profile, with secondary outcomes including objective response rate, progression-free survival, and overall survival. (Nature

Cetuximab Rechallenge Tested Against Regorafenib in RAS Wild-Type mCRC

Skip to content The CRC Digest ◆ TRIAL DATA Cetuximab Rechallenge Tested Against Regorafenib in RAS Wild-Type mCRC A single-center randomized trial evaluated cetuximab plus irinotecan rechallenge versus regorafenib in RAS wild-type, microsatellite-stable metastatic colorectal cancer patients who had previously responded to then progressed off cetuximab, with progression-free survival as the

CRISPR Screens Reveal How MSI-H Tumors Depend on WRN Helicase

Skip to content The CRC Digest ◇ RESEARCH CRISPR Screens Reveal How MSI-H Tumors Depend on WRN Helicase Genome-wide CRISPR screens identified SMARCAL1 as a key modulator of WRN dependency in MSI-H colorectal cancer, with loss of SMARCAL1 rendering cells resistant to the WRN inhibitor HRO761. The findings shed light on

Review highlights accessible blood-based biomarkers for CRC detection

Skip to content The CRC Digest ◇ RESEARCH Review highlights accessible blood-based biomarkers for CRC detection A systematic review synthesizes circulating transcriptomic and proteomic biomarkers detectable by widely available RT-PCR and ELISA platforms, aiming to bridge the gap between high-throughput research and clinically scalable diagnostics. (Crit Rev Clin Lab Sci) This

Machine learning model predicts liver metastasis risk after colorectal cancer surgery

Skip to content The CRC Digest ◇ RESEARCH Machine learning model predicts liver metastasis risk after colorectal cancer surgery A multicenter study developed an AI-integrated model using clinical, laboratory, and CT imaging data to predict which stage I–III CRC patients will develop metachronous liver metastasis within 5 years after radical

Dual KRAS Y96C/Y96S resistance mutations emerge after KRAS G12C inhibitor therapy

Skip to content The CRC Digest ◇ RESEARCH Dual KRAS Y96C/Y96S resistance mutations emerge after KRAS G12C inhibitor therapy Liquid biopsy detected concurrent Y96S and Y96C mutations in a patient with KRAS G12C-mutated metastatic CRC who progressed after 9.3 months of KRAS G12C inhibitor monotherapy; these polyclonal alterations were

First-line immunotherapy outperforms chemotherapy in MSI-H/dMMR metastatic colorectal cancer

Skip to content The CRC Digest ◆ TRIAL DATA First-line immunotherapy outperforms chemotherapy in MSI-H/dMMR metastatic colorectal cancer A meta-analysis of phase III trials confirms immune checkpoint inhibitors show superior progression-free and overall survival compared to standard chemotherapy as first-line treatment for patients with MSI-H or dMMR metastatic disease. (J

CRC Research Update — July 20, 2026

Today's colorectal cancer research highlights

Anastomotic leakage shows minimal long-term impact on quality of life after rectal cancer surgery

Skip to content The CRC Digest ♥ LIVING WITH CRC Anastomotic leakage shows minimal long-term impact on quality of life after rectal cancer surgery A Swedish population-based study found that while anastomotic leakage after anterior resection is associated with long-term bowel dysfunction, its impact on health-related quality of life 3 years