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DR5-Lig3 feedback loop may shape immunotherapy response in dMMR colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH DR5-Lig3 feedback loop may shape immunotherapy response in dMMR colorectal cancer New research identifies a molecular pathway that may influence how mismatch repair-deficient tumors respond to immunotherapy. (BioPharm International) This content is informational only and does not constitute medical advice. Always consult your

Circulating tumor DNA may identify which patients benefit from chemotherapy after liver metastasis surgery

Skip to content The CRC Digest ◆ TRIAL DATA Circulating tumor DNA may identify which patients benefit from chemotherapy after liver metastasis surgery The phase II GALAXY study (298 patients) found that ctDNA testing 2-10 weeks after surgery for colorectal liver metastases could help predict which patients are most likely to

Phase III trial finds no survival benefit from adding chemotherapy to surgery for peritoneal metastases

Skip to content The CRC Digest ◆ TRIAL DATA Phase III trial finds no survival benefit from adding chemotherapy to surgery for peritoneal metastases The CAIRO6 trial (351 patients) found that perioperative systemic therapy did not significantly improve overall survival compared to surgery alone in patients with resectable peritoneal-only metastases (44

CRC Research Update — July 19, 2026

Today's colorectal cancer research highlights

Oncogenic KRAS drives xCT upregulation and ferroptosis evasion through CCDC6 degradation

Skip to content The CRC Digest Oncogenic KRAS drives xCT upregulation and ferroptosis evasion through CCDC6 degradation Researchers identified a mechanism by which KRAS mutations promote tumor cell survival by degrading the CCDC6 tumor suppressor, leading to increased xCT expression and protection from oxidative stress. (Apoptosis) This content is informational

Case-control study compares metabolic and laboratory biomarkers in early-onset versus late-onset colorectal cancer

Skip to content The CRC Digest Case-control study compares metabolic and laboratory biomarkers in early-onset versus late-onset colorectal cancer Researchers used a large US database to compare metabolic, inflammatory, and laboratory abnormalities between patients diagnosed at ages 18-49 versus 50-75. (Cancers) This content is informational only and does not constitute

First Nations people in Ontario experience higher colon cancer incidence at younger ages

Skip to content The CRC Digest First Nations people in Ontario experience higher colon cancer incidence at younger ages New evidence shows registered First Nations people have higher colon cancer incidence at younger ages and poorer survival after breast, cervical, and colon cancer diagnoses than other Ontario residents. (The Lancet

Single-section PMS2/MSH6 double immunohistochemistry shows promise as screening tool for mismatch repair deficiency

Skip to content The CRC Digest ◇ RESEARCH Single-section PMS2/MSH6 double immunohistochemistry shows promise as screening tool for mismatch repair deficiency A study of 794 colorectal and endometrial cancer cases evaluated whether a single-section test could accurately identify deficient mismatch repair (dMMR) status. (Human Pathology) This content is informational only

Long-term outcomes reported for neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer

Skip to content The CRC Digest ▸ TREATMENT Long-term outcomes reported for neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer A multicentre study followed patients treated with bevacizumab combined with chemoradiation before surgery for locally advanced rectal cancer. (Clinical Colorectal Cancer) This content is informational only and does not constitute

Systematic review and meta-analysis quantifies sensitivity and specificity of fecal immunochemical testing and colonoscopy for colorectal cancer screening

Skip to content The CRC Digest ▪ SCREENING Systematic review and meta-analysis quantifies sensitivity and specificity of fecal immunochemical testing and colonoscopy for colorectal cancer screening Researchers analyzed multiple studies to estimate the accuracy of two major screening tests in asymptomatic average-risk adults. (Preventive Medicine Reports) This content is informational only