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Machine learning model predicts liver metastasis risk after colorectal cancer surgery

Skip to content The CRC Digest ◇ RESEARCH Machine learning model predicts liver metastasis risk after colorectal cancer surgery A multicenter study developed an AI-integrated model using clinical, laboratory, and CT imaging data to predict which stage I–III CRC patients will develop metachronous liver metastasis within 5 years after radical

Dual KRAS Y96C/Y96S resistance mutations emerge after KRAS G12C inhibitor therapy

Skip to content The CRC Digest ◇ RESEARCH Dual KRAS Y96C/Y96S resistance mutations emerge after KRAS G12C inhibitor therapy Liquid biopsy detected concurrent Y96S and Y96C mutations in a patient with KRAS G12C-mutated metastatic CRC who progressed after 9.3 months of KRAS G12C inhibitor monotherapy; these polyclonal alterations were

First-line immunotherapy outperforms chemotherapy in MSI-H/dMMR metastatic colorectal cancer

Skip to content The CRC Digest ◆ TRIAL DATA First-line immunotherapy outperforms chemotherapy in MSI-H/dMMR metastatic colorectal cancer A meta-analysis of phase III trials confirms immune checkpoint inhibitors show superior progression-free and overall survival compared to standard chemotherapy as first-line treatment for patients with MSI-H or dMMR metastatic disease. (J

CRC Research Update — July 20, 2026

Today's colorectal cancer research highlights

Anastomotic leakage shows minimal long-term impact on quality of life after rectal cancer surgery

Skip to content The CRC Digest ♥ LIVING WITH CRC Anastomotic leakage shows minimal long-term impact on quality of life after rectal cancer surgery A Swedish population-based study found that while anastomotic leakage after anterior resection is associated with long-term bowel dysfunction, its impact on health-related quality of life 3 years

DR5-Lig3 feedback loop may shape immunotherapy response in dMMR colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH DR5-Lig3 feedback loop may shape immunotherapy response in dMMR colorectal cancer New research identifies a molecular pathway that may influence how mismatch repair-deficient tumors respond to immunotherapy. (BioPharm International) This content is informational only and does not constitute medical advice. Always consult your

Circulating tumor DNA may identify which patients benefit from chemotherapy after liver metastasis surgery

Skip to content The CRC Digest ◆ TRIAL DATA Circulating tumor DNA may identify which patients benefit from chemotherapy after liver metastasis surgery The phase II GALAXY study (298 patients) found that ctDNA testing 2-10 weeks after surgery for colorectal liver metastases could help predict which patients are most likely to

Phase III trial finds no survival benefit from adding chemotherapy to surgery for peritoneal metastases

Skip to content The CRC Digest ◆ TRIAL DATA Phase III trial finds no survival benefit from adding chemotherapy to surgery for peritoneal metastases The CAIRO6 trial (351 patients) found that perioperative systemic therapy did not significantly improve overall survival compared to surgery alone in patients with resectable peritoneal-only metastases (44

CRC Research Update — July 19, 2026

Today's colorectal cancer research highlights

Oncogenic KRAS drives xCT upregulation and ferroptosis evasion through CCDC6 degradation

Skip to content The CRC Digest Oncogenic KRAS drives xCT upregulation and ferroptosis evasion through CCDC6 degradation Researchers identified a mechanism by which KRAS mutations promote tumor cell survival by degrading the CCDC6 tumor suppressor, leading to increased xCT expression and protection from oxidative stress. (Apoptosis) This content is informational