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A collection of 632 issues

Tracking ctDNA after surgery identifies high-risk patients despite negative MRD status

Skip to content The CRC Digest ◇ RESEARCH Tracking ctDNA after surgery identifies high-risk patients despite negative MRD status A longitudinal study of 124 stage II-III patients found that analyzing circulating tumor DNA (ctDNA) trajectories after surgery can identify subgroups at high risk for recurrence or metastasis, even when initial minimal

COMMIT trial analysis examines chemoimmunotherapy in dMMR metastatic CRC

Skip to content The CRC Digest ◆ TRIAL DATA COMMIT trial analysis examines chemoimmunotherapy in dMMR metastatic CRC A new analysis explores what the COMMIT trial can and cannot tell us about combining chemotherapy with immunotherapy in patients with deficient DNA mismatch repair metastatic colorectal cancer. (Journal of Clinical Oncology) This

Blood-based screening may reduce barriers for adults with intellectual disabilities

Skip to content The CRC Digest ▪ SCREENING Blood-based screening may reduce barriers for adults with intellectual disabilities Adults with intellectual and developmental disabilities face substantial barriers to CRC screening, and blood-based tests may reduce logistical barriers, though current Medicaid coverage gaps limit accessibility for this population. (Cureus) This content is

CRC burden rising fastest in adults under 50

Skip to content The CRC Digest ▪ SCREENING CRC burden rising fastest in adults under 50 Analysis of GBD 2023 data found CRC incidence rose most in adults aged 15-44 (+16.8%). (Annals of Medicine) This content is informational only and does not constitute medical advice. Always consult your oncologist or

Pre-chemotherapy anxiety and sleep disturbance linked to immune changes and quality of life

Skip to content The CRC Digest ♥ LIVING WITH CRC Pre-chemotherapy anxiety and sleep disturbance linked to immune changes and quality of life A prospective study of 268 CRC patients assessed within 24 hours before their first chemotherapy cycle found that anxiety-sleep disturbance symptoms were associated with neuroendocrine dysregulation, cellular immune

Smartphone-based education program for family caregivers of CRC patients

Skip to content The CRC Digest ♥ LIVING WITH CRC Smartphone-based education program for family caregivers of CRC patients A randomized controlled trial of 80 family caregivers of CRC patients tested a smartphone-based educational program designed to meet supportive care needs compared to routine care, with assessments completed before and 4

Real-world data on HER2-positive metastatic CRC from 14 Japanese centers

Skip to content The CRC Digest ◇ RESEARCH Real-world data on HER2-positive metastatic CRC from 14 Japanese centers A multicenter retrospective study of 45 patients with HER2-positive metastatic colorectal cancer diagnosed between 2010 and 2023 examined outcomes with different first-line targeted agents and assessed safety of trastuzumab plus pertuzumab. (International Journal

American Cancer Society adds blood-based tests to CRC screening guidelines

Skip to content The CRC Digest ▪ SCREENING American Cancer Society adds blood-based tests to CRC screening guidelines In May 2026, the American Cancer Society updated their recommendations to include blood-based tests for individuals who decline or do not complete preferred screening tests, with a colonoscopy within 6 months required for

Immune Recovery After Surgery Linked to ctDNA Minimal Residual Disease

Skip to content The CRC Digest Immune Recovery After Surgery Linked to ctDNA Minimal Residual Disease A prospective study of 1,000 stage II-III CRC patients found that distinct perioperative immunocircadian recovery trajectories were associated with postoperative ctDNA-based minimal residual disease and long-term survival outcomes. (Surgery) This content is informational

Biological Age and Neighborhood Deprivation Linked to Psychological Distress During Chemotherapy

Skip to content The CRC Digest ♥ LIVING WITH CRC Biological Age and Neighborhood Deprivation Linked to Psychological Distress During Chemotherapy An analysis of 958 adults with stage II-III CRC receiving chemotherapy found that biological age and neighborhood deprivation predict depression and anxiety symptoms, highlighting biosocial factors that may influence mental