BRAF V600E triplet regimen advances in phase 3 trial Skip to content The CRC Digest BRAF V600E triplet regimen advances in phase 3 trial BREAKWATER Cohort 3 evaluated encorafenib + cetuximab + FOLFIRI versus FOLFIRI ± bevacizumab in previously untreated BRAF V600E-mutant mCRC, with primary endpoint of objective response rate and key secondary endpoint of progression-free survival. (Annals of Oncology) This content
RAS/BRAF wild-type patients: Maintenance strategies compared Skip to content The CRC Digest RAS/BRAF wild-type patients: Maintenance strategies compared Three trials pooled data on left-sided, RAS/BRAF wild-type metastatic CRC to compare toxicity profiles of different maintenance approaches. (Journal of the National Cancer Institute) This content is informational only and does not constitute medical advice. Always
Prolonged Response to Pembrolizumab in BRAF V600E MSS Colorectal Cancer Skip to content The CRC Digest Prolonged Response to Pembrolizumab in BRAF V600E MSS Colorectal Cancer A patient with BRAF V600E-mutant microsatellite-stable metastatic colorectal cancer achieved a prolonged response to pembrolizumab following a dynamic increase in tumor mutational burden. (The Oncologist) This content is informational only and does not constitute