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crc-research

A collection of 715 issues

Adjuvant chemotherapy benefits occur early, not in late recurrences

Skip to content The CRC Digest ◆ TRIAL DATA Adjuvant chemotherapy benefits occur early, not in late recurrences A systematic review of phase III randomized controlled trials for gastrointestinal malignancies including colorectal cancer found that recurrence-free survival improvements were driven by early divergences during active chemotherapy, while late recurrences were not

New gene circuit platform targets multiple KRAS mutations in preclinical models

Skip to content The CRC Digest ◇ RESEARCH New gene circuit platform targets multiple KRAS mutations in preclinical models Researchers developed a platform that enables in vivo self-assembly of small extracellular vesicles encapsulating KRAS-specific siRNAs for broad targeting of KRAS mutants, showing activity in orthotopic models of KRAS G12D-, G12V-, and

Trifluridine/tipiracil outcomes examined in patients 75 and older

Skip to content The CRC Digest ▸ TREATMENT Trifluridine/tipiracil outcomes examined in patients 75 and older A single-center retrospective study compared relative dose intensity, toxicity, and survival between trifluridine/tipiracil (FTD/TPI) monotherapy and FTD/TPI plus bevacizumab in older patients with metastatic colorectal cancer, examining the relationship between dose

Multitarget stool DNA test shows promise over standard FIT screening

Skip to content The CRC Digest ▪ SCREENING Multitarget stool DNA test shows promise over standard FIT screening A systematic review found that multitarget stool DNA (mt-sDNA) testing emerged as a promising alternative to faecal immunochemical test (FIT) for detecting colorectal neoplasms, particularly given FIT's low sensitivity for advanced

CRC Research Update — August 14, 2026

Today's colorectal cancer research highlights

Younger CRC Patients Face Distinct Quality of Life Challenges

Skip to content The CRC Digest Younger CRC Patients Face Distinct Quality of Life Challenges A qualitative study comparing early-onset colorectal cancer patients to older patients found that young people with colorectal cancer experience worse psychological wellbeing, including marked emotional distress and prominent levels of anxiety. (Quality of Life Research)

Rare DPYD Variant Linked to Severe Fluoropyrimidine Toxicity

Skip to content The CRC Digest ▸ TREATMENT Rare DPYD Variant Linked to Severe Fluoropyrimidine Toxicity A 50-year-old colorectal cancer patient developed life-threatening grade 3-4 toxicities after adjuvant XELOX; sequencing identified a rare intronic DPYD variant (c.2766+3A>T) that causes exon 21 skipping and profound DPD deficiency, which

Anorectal Visits Offer Missed Screening Opportunity for Adults Under 50

Skip to content The CRC Digest ▪ SCREENING Anorectal Visits Offer Missed Screening Opportunity for Adults Under 50 Among 776 patients seen for benign anorectal conditions, only 60.5% of adults aged 45-49 had undergone colonoscopy in the prior 10 years, highlighting a missed opportunity to promote screening during routine visits.

Sotorasib Plus Panitumumab Compared to Standard Therapy in Chemorefractory Metastatic CRC

Skip to content The CRC Digest ▸ TREATMENT Sotorasib Plus Panitumumab Compared to Standard Therapy in Chemorefractory Metastatic CRC A matching-adjusted indirect comparison evaluated sotorasib plus panitumumab versus trifluridine/tipiracil plus bevacizumab in chemorefractory metastatic colorectal cancer. (Clinical Colorectal Cancer) This content is informational only and does not constitute medical advice.

KRAS Mutations and Liver Metastases Predict Worse Outcomes in Third-Line Metastatic CRC

Skip to content The CRC Digest ◇ RESEARCH KRAS Mutations and Liver Metastases Predict Worse Outcomes in Third-Line Metastatic CRC A pooled analysis of placebo-controlled trials from the ARCAD CRC Database found that KRAS mutations and liver metastases are independently associated with poorer prognosis in patients receiving third-line therapy for metastatic