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lynch-syndrome

A collection of 7 issues

Immunotherapy transforms surgical decisions in Lynch syndrome CRC

Skip to content The CRC Digest Immunotherapy transforms surgical decisions in Lynch syndrome CRC Narrative review examines how immune checkpoint inhibitors achieving 60-100% pathological complete response rates in MSI-H/dMMR CRC are challenging traditional recommendations for extensive prophylactic surgery in Lynch syndrome patients. (European Journal of Surgical Oncology) This content

CRC Research Update — June 06, 2026

Today's colorectal cancer research highlights

CRC Research Update — June 04, 2026

Today's colorectal cancer research highlights

CRC Research Update — May 13, 2026

Today's colorectal cancer research highlights

CRC Research Update — May 12, 2026

Today's colorectal cancer research highlights

Five Decades of Familial Adenomatous Polyposis Surveillance in Denmark

Skip to content The CRC Digest Five Decades of Familial Adenomatous Polyposis Surveillance in Denmark A study from the Danish Polyposis Register emphasizes the importance of lifelong endoscopic surveillance and tailored treatment strategies for FAP patients, who face elevated risks for duodenal and pancreatic cancers even after colectomy. (APMIS) This

Nous-209 Immunotherapy Targets Appear Early in Lynch Syndrome Precancers

Skip to content The CRC Digest Nous-209 Immunotherapy Targets Appear Early in Lynch Syndrome Precancers In a study of Lynch syndrome carriers, 83% of advanced adenomas and 58% of adenomas were mismatch repair-deficient, and the presence of Nous-209 mutations correlated strongly with microsatellite instability status, suggesting potential for preventive immunotherapy.