CRC Research Update — October 12, 2026
Today's colorectal cancer research highlights
lynch-syndrome
A collection of 46 issues
Colon cancer diagnosed in 41-year-old woman with mosaic NF1 variant
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The CRC Digest
◇ RESEARCH
Colon cancer diagnosed in 41-year-old woman with mosaic NF1 variant
A case report describes a 41-year-old woman with a mosaic monoallelic germline pathogenic NF1 variant who developed colon cancer, highlighting the underreported relationship between NF1 variation and colorectal cancer risk. (Explor Neurosci)
This
CRC Research Update — October 05, 2026
Today's colorectal cancer research highlights
CRC Research Update — September 15, 2026
Today's colorectal cancer research highlights
CRC Research Update — September 12, 2026
Today's colorectal cancer research highlights
39-year-old proband with Lynch syndrome shows discordant tumor testing
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The CRC Digest
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39-year-old proband with Lynch syndrome shows discordant tumor testing
A 39-year-old man with colorectal cancer and family history fulfilling Amsterdam criteria carried the germline MLH1 c.931A>G variant, with tumors showing MSI-H status despite retained MMR protein expression. (Clinical Case Reports)
Lynch syndrome family shows MSI-H tumors despite preserved MMR protein staining
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The CRC Digest
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Lynch syndrome family shows MSI-H tumors despite preserved MMR protein staining
A family carrying germline MLH1 c.931A>G presented with colorectal tumors showing retained mismatch repair protein expression by immunohistochemistry but microsatellite instability-high status on sequencing, highlighting that preserved staining does
CRC Research Update — September 11, 2026
Today's colorectal cancer research highlights
Lynch syndrome diagnosis rate in China far below expected prevalence
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The CRC Digest
Lynch syndrome diagnosis rate in China far below expected prevalence
A national survey of 81 physicians from 81 Chinese hospitals found a Lynch syndrome diagnosis rate of only 0.83% versus the expected 2-3%, despite 95.1% of hospitals offering dMMR immunohistochemistry. (Familial Cancer)
CRC Research Update — September 05, 2026
Today's colorectal cancer research highlights