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lynch-syndrome

A collection of 50 issues

Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases

Skip to content The CRC Digest ▪ SCREENING Universal Tumor Screening Evaluated for Lynch Syndrome Detection in 1,022 Consecutive CRC Cases A University Hospital of Padua study assessed mismatch repair deficiency distribution and Lynch syndrome detection rates across clinical subgroups using immunohistochemistry-based universal tumor screening in consecutive surgical patients. (Cancers)

CRC Research Update — August 23, 2026

Today's colorectal cancer research highlights

Amino-acid biomarkers studied for Lynch syndrome surveillance

Skip to content The CRC Digest Amino-acid biomarkers studied for Lynch syndrome surveillance A prospective study is evaluating whether faecal and urinary amino-acids can help refine colonoscopy surveillance in individuals with Lynch syndrome, potentially reducing the burden of frequent screening. (International Journal of Cancer) This content is informational only and

CRC Research Update — August 17, 2026

Today's colorectal cancer research highlights

MLH1-Deficient Lynch Syndrome Case Highlights Management Dilemma

Skip to content The CRC Digest MLH1-Deficient Lynch Syndrome Case Highlights Management Dilemma The co-occurrence of a germline MLH1 pathogenic variant and a GALT/dome carcinoma raises questions about optimal management in the absence of high-risk histologic features. (ACG Case Rep J) This content is informational only and does not

Rare GALT/Dome Carcinoma Found in Woman With Lynch Syndrome

Skip to content The CRC Digest Rare GALT/Dome Carcinoma Found in Woman With Lynch Syndrome A woman in her early 40s with MLH1-deficient Lynch syndrome was incidentally found to have a cecal GALT/dome carcinoma during routine surveillance, raising management questions about prophylactic colectomy versus endoscopic surveillance. (ACG Case

CRC Research Update — August 15, 2026

Today's colorectal cancer research highlights

Significant discrepancies found in early-onset CRC among neglected populations

Skip to content The CRC Digest Significant discrepancies found in early-onset CRC among neglected populations A comprehensive review evaluating genetic and molecular research on hereditary and early-onset CRC in ethnic minority, indigenous, and understudied populations found significant discrepancies in early-onset CRC presentations compared with well-studied groups, despite largely consistent Lynch

CRC Research Update — August 13, 2026

Today's colorectal cancer research highlights

Serbian cohort reveals MLH1 as predominant Lynch syndrome variant

Skip to content The CRC Digest Serbian cohort reveals MLH1 as predominant Lynch syndrome variant Germline testing of 176 high-risk individuals in Serbia identified pathogenic variants predominantly in MLH1, highlighting the need for population-specific genetic testing strategies in hereditary colorectal cancer screening. (Int J Mol Sci) This content is informational