Dual immunotherapy shows durable benefit in MSI-H colorectal cancer Skip to content The CRC Digest ◆ TRIAL DATA Dual immunotherapy shows durable benefit in MSI-H colorectal cancer — Journal of Clinical Oncology Long-term follow-up from the CheckMate 8HW phase 3 trial examined outcomes in patients with MSI-H/dMMR (microsatellite instability-high/mismatch repair-deficient) metastatic colorectal cancer treated with nivolumab plus ipilimumab versus
Nous-209 Immunotherapy Targets Appear Early in Lynch Syndrome Precancers Skip to content The CRC Digest Nous-209 Immunotherapy Targets Appear Early in Lynch Syndrome Precancers In a study of Lynch syndrome carriers, 83% of advanced adenomas and 58% of adenomas were mismatch repair-deficient, and the presence of Nous-209 mutations correlated strongly with microsatellite instability status, suggesting potential for preventive immunotherapy.