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precancer

A collection of 138 issues

Fusobacterium nucleatum Detected in 11% of Adenomas, Linked to Immune Signatures

Skip to content The CRC Digest ◇ RESEARCH Fusobacterium nucleatum Detected in 11% of Adenomas, Linked to Immune Signatures RNA-based detection found Fusobacterium nucleatum in 11% of adenoma tissue samples, with positive patients exhibiting enriched anti-bacterial defense response and immune-related transcriptomic signatures compared to negative patients. (International Journal of Molecular Sciences)

Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy

Skip to content The CRC Digest ▪ SCREENING Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy A retrospective study of 800 adults from a US health-system biobank who underwent colonoscopy between 2010 and 2025 found that inherited genetic risk may improve yield of adenoma detection and prioritization of colonoscopy

Blood Test Combining cfDNA Fragmentomics and Methylation Markers Detects Precancerous Lesions

Skip to content The CRC Digest ▪ SCREENING Blood Test Combining cfDNA Fragmentomics and Methylation Markers Detects Precancerous Lesions A study of 380 CRC patients, 121 individuals with precancerous lesions, and 506 healthy controls found that adding methylation analysis of SEPT9 and HS3ST2 to cfDNA fragmentomic features improved detection of precancerous

CRC Research Update — August 27, 2026

Today's colorectal cancer research highlights

CONFIRM trial examines race, ethnicity, and screening test use among Veterans

Skip to content The CRC Digest ▪ SCREENING CONFIRM trial examines race, ethnicity, and screening test use among Veterans A study of 50,125 US Veteran participants in a randomized trial comparing colonoscopy to annual fecal immunochemical testing examined how race, ethnicity, and access to care factors relate to screening test

CRC Research Update — August 26, 2026

Today's colorectal cancer research highlights

Gut microbiome profiles improve detection of precancerous lesions in FIT screening

Skip to content The CRC Digest ▪ SCREENING Gut microbiome profiles improve detection of precancerous lesions in FIT screening In a Norwegian study of 1,034 FIT-positive screening participants, combining microbial profiles with quantitative FIT values improved detection of premalignant lesions beyond optimizing the FIT value alone. (Nat Commun) This content

CRC Research Update — August 25, 2026

Today's colorectal cancer research highlights

New model suggests accelerated colorectal carcinogenesis may limit screening effectiveness

Skip to content The CRC Digest ▪ SCREENING New model suggests accelerated colorectal carcinogenesis may limit screening effectiveness Researchers propose an exposure-driven accelerated carcinogenesis model to explain rising early-onset CRC, increasing distal and rectal tumors, and post-colonoscopy CRC despite high-quality screening, suggesting that current slowly progressive models may not fully capture

CRC Research Update — August 23, 2026

Today's colorectal cancer research highlights