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prospective

A collection of 92 issues

Seven-Year Study Maps Dysplasia Patterns in Sessile Serrated Lesions

Skip to content The CRC Digest ▪ SCREENING Seven-Year Study Maps Dysplasia Patterns in Sessile Serrated Lesions A retrospective analysis of all sessile serrated lesions from a single high-detection-rate endoscopist in Australia assessed the prevalence and anatomical distribution of dysplasia, a critical stage in progression to colorectal cancer. (Gastroenterology and Hepatology

Urinary Metabolomics May Improve Survival Prediction Beyond Tumor Stage

Skip to content The CRC Digest ◇ RESEARCH Urinary Metabolomics May Improve Survival Prediction Beyond Tumor Stage Pre-surgery urinary metabolomic profiles improved overall survival prediction performance compared with stage- and age-based models in 76 stage I-IV CRC patients from the ColoCare Study. (Metabolomics) This content is informational only and does not

Network analysis reveals symptom cluster stability during adjuvant chemotherapy

Skip to content The CRC Digest ♥ LIVING WITH CRC Network analysis reveals symptom cluster stability during adjuvant chemotherapy A prospective longitudinal study used network temperature to characterize temporal changes in symptom clusters among postoperative colorectal cancer patients receiving adjuvant chemotherapy, finding that symptom burden compromises quality of life. (Supportive Care

Blood test combining cfDNA fragmentomics and methylation markers detects precancerous lesions

Skip to content The CRC Digest ▪ SCREENING Blood test combining cfDNA fragmentomics and methylation markers detects precancerous lesions A study of 380 CRC patients, 121 individuals with precancerous lesions, and 506 healthy controls found that adding methylation analysis of SEPT9 and HS3ST2 to cfDNA fragmentomics improved detection of precancerous lesions,

Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals

Skip to content The CRC Digest ▪ SCREENING Machine Learning Model Combines FIT with Clinical Data to Triage Fast-Track Colonoscopy Referrals Swedish researchers developed and externally validated risk models combining faecal immunochemical test results with age, sex, symptoms, and imaging to prioritize 2,539 fast-track colonoscopies, aiming to improve endoscopy capacity.

Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment

Skip to content The CRC Digest ◇ RESEARCH Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment Accelerometer data from 358 colorectal cancer patients revealed three activity profiles: most sedentary (16%), average (53%), and highly active (31%). (J Cancer Surviv) This content is informational only and does not constitute

Tracking ctDNA after surgery identifies high-risk patients despite negative MRD status

Skip to content The CRC Digest ◇ RESEARCH Tracking ctDNA after surgery identifies high-risk patients despite negative MRD status A longitudinal study of 124 stage II-III patients found that analyzing circulating tumor DNA (ctDNA) trajectories after surgery can identify subgroups at high risk for recurrence or metastasis, even when initial minimal

Pre-chemotherapy anxiety and sleep disturbance linked to immune changes and quality of life

Skip to content The CRC Digest ♥ LIVING WITH CRC Pre-chemotherapy anxiety and sleep disturbance linked to immune changes and quality of life A prospective study of 268 CRC patients assessed within 24 hours before their first chemotherapy cycle found that anxiety-sleep disturbance symptoms were associated with neuroendocrine dysregulation, cellular immune

Immune Recovery After Surgery Linked to ctDNA Minimal Residual Disease

Skip to content The CRC Digest Immune Recovery After Surgery Linked to ctDNA Minimal Residual Disease A prospective study of 1,000 stage II-III CRC patients found that distinct perioperative immunocircadian recovery trajectories were associated with postoperative ctDNA-based minimal residual disease and long-term survival outcomes. (Surgery) This content is informational

Biological Age and Neighborhood Deprivation Linked to Psychological Distress During Chemotherapy

Skip to content The CRC Digest ♥ LIVING WITH CRC Biological Age and Neighborhood Deprivation Linked to Psychological Distress During Chemotherapy An analysis of 958 adults with stage II-III CRC receiving chemotherapy found that biological age and neighborhood deprivation predict depression and anxiety symptoms, highlighting biosocial factors that may influence mental