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prospective

A collection of 92 issues

French multicenter study to evaluate ctDNA after liver metastasis surgery

Skip to content The CRC Digest French multicenter study to evaluate ctDNA after liver metastasis surgery The CLIMES PRODIGE 77 study will enroll 232 patients undergoing curative-intent liver metastasis resection to evaluate circulating tumor DNA as a biomarker for detecting minimal residual disease and predicting prognosis. (BMJ Open) This content

Blood protein biomarkers outperform traditional risk models for early CRC detection

Skip to content The CRC Digest Blood protein biomarkers outperform traditional risk models for early CRC detection A protein score developed from 53,073 participants showed superior performance compared to models using age, BMI, smoking, and family history. (Cancer Epidemiol Biomarkers Prev) This content is informational only and does not

Pelvic floor rehabilitation addresses bowel dysfunction and quality of life after rectal cancer

Skip to content The CRC Digest Pelvic floor rehabilitation addresses bowel dysfunction and quality of life after rectal cancer Fourteen survivors shared experiences with structured pelvic floor programs that support bowel function recovery and address psychosocial impacts of low anterior resection syndrome. (Support Care Cancer) This content is informational only

CRC Research Finding

Skip to content The CRC Digest ♥ Structured pelvic floor rehabilitation helps survivors manage bowel dysfunction after rectal cancer surgery A qualitative study of 14 colorectal cancer survivors found that structured pelvic floor rehabilitation programs address low anterior resection syndrome, a common challenge affecting bowel function, psychosocial health, and daily living

Colonoscope-Derived Mucus Detects KRAS Mutations in Precancerous Lesions

Skip to content The CRC Digest Colonoscope-Derived Mucus Detects KRAS Mutations in Precancerous Lesions A prospective pilot study found that mucus collected from the colonoscope sheath during routine colonoscopy serves as a high-fidelity source of cell-free DNA for detecting KRAS-mutated colorectal neoplasia. (Translational Oncology) This content is informational only and

CRC Research Finding

Skip to content The CRC Digest ▪ Younger individuals with family history show increased advanced adenoma risk Study of 409 patients undergoing early screening colonoscopy due to first-degree relative with advanced polyps found increased prevalence of advanced adenomas in younger individuals, supporting current early screening guidelines. (Gastroenterology and Hepatology Advances) This

CRC Research Finding

Skip to content The CRC Digest ▪ Screening test preferences vary by sociodemographic factors in underserved populations A survey of 1,014 adults aged 45-75 across community health centers found that preferences for stool test, blood test, and colonoscopy varied by sociodemographic factors and health beliefs, highlighting the need to understand

Quality of life data for watch-and-wait versus surgery

Skip to content The CRC Digest Quality of life data for watch-and-wait versus surgery Study provides quality of life comparisons to help rectal cancer patients and clinicians weigh treatment options after complete response. (Clinical Colorectal Cancer) This content is informational only and does not constitute medical advice. Always consult your

Nous-209 Immunotherapy Targets Appear Early in Lynch Syndrome Precancers

Skip to content The CRC Digest Nous-209 Immunotherapy Targets Appear Early in Lynch Syndrome Precancers In a study of Lynch syndrome carriers, 83% of advanced adenomas and 58% of adenomas were mismatch repair-deficient, and the presence of Nous-209 mutations correlated strongly with microsatellite instability status, suggesting potential for preventive immunotherapy.

Patients Describe Complex Impact of Chemo Brain on Daily Life

Skip to content The CRC Digest Patients Describe Complex Impact of Chemo Brain on Daily Life Qualitative study identifies how cognitive impairment from chemotherapy affects memory, concentration, and emotional health in colorectal cancer patients. (Journal of Health Psychology) This content is informational only and does not constitute medical advice. Always