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radiation

A collection of 6 issues

Intensified Total Neoadjuvant Therapy Improves Survival in High-Risk Rectal Cancer

Skip to content The CRC Digest ◆ TRIAL DATA Intensified Total Neoadjuvant Therapy Improves Survival in High-Risk Rectal Cancer A Chinese phase III trial of 458 patients with high-risk locally advanced rectal cancer found that integrating long-course radiotherapy with uninterrupted capecitabine and oxaliplatin chemotherapy (doublet-LC TNT) achieved 3-year disease-free survival of

KRAS Mutation Subtypes May Influence Response to Neoadjuvant Therapy in Rectal Cancer

Skip to content The CRC Digest ◇ RESEARCH KRAS Mutation Subtypes May Influence Response to Neoadjuvant Therapy in Rectal Cancer A meta-analysis investigated whether different KRAS mutation subtypes affect pathological complete response rates after neoadjuvant chemoradiotherapy in locally advanced rectal cancer. The study examined KRAS mutations within and outside exon 2.

AI tool identifies rectal cancer patients who benefit from intensified chemoradiotherapy

Skip to content The CRC Digest ◇ RESEARCH AI tool identifies rectal cancer patients who benefit from intensified chemoradiotherapy A post-hoc analysis of the phase III ARISTOTLE trial found that higher tumor cell density predicted improved survival in locally advanced rectal cancer patients receiving irinotecan-intensified neoadjuvant chemoradiotherapy; researchers developed a free

Phase III Trial Compares Total Neoadjuvant Therapy Approaches in High-Risk Rectal Cancer

Skip to content The CRC Digest ◆ TRIAL DATA Phase III Trial Compares Total Neoadjuvant Therapy Approaches in High-Risk Rectal Cancer A multicenter, randomized phase III trial evaluated total neoadjuvant therapy with long-course radiotherapy versus chemoradiotherapy in patients with high-risk locally advanced rectal cancer. (Journal of Clinical Oncology) This content is

Phase Ib FIERCE Study Assesses Trifluridine/Tipiracil With Radiation in Rectal Cancer

Skip to content The CRC Digest ◆ TRIAL DATA Phase Ib FIERCE Study Assesses Trifluridine/Tipiracil With Radiation in Rectal Cancer A phase Ib study to assess the safety of neoadjuvant trifluridine/tipiracil combined with concurrent radiation in patients with resectable stage II/III rectal cancer. (Clinical Colorectal Cancer) This content

Long-term outcomes reported for neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer

Skip to content The CRC Digest ▸ TREATMENT Long-term outcomes reported for neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer A multicentre study followed patients treated with bevacizumab combined with chemoradiation before surgery for locally advanced rectal cancer. (Clinical Colorectal Cancer) This content is informational only and does not constitute