ctDNA in the Management of Resectable & Advanced Colorectal Cancer Skip to content The CRC Digest ◇ RESEARCH ctDNA in the Management of Resectable & Advanced Colorectal Cancer A structured narrative review synthesizes evidence on circulating tumor DNA as a biomarker for molecular residual disease after curative-intent treatment, covering tumor-informed and tumor-agnostic assay strategies, postoperative sampling, and serial versus landmark testing
Meta-analysis shows ctDNA after surgery strongly predicts recurrence risk Skip to content The CRC Digest ◇ RESEARCH Meta-analysis shows ctDNA after surgery strongly predicts recurrence risk A meta-analysis of seven prospective cohorts found that postoperative circulating tumor DNA positivity was associated with increased recurrence risk (pooled hazard ratio, 7.60; 95% CI, 4.70-12.31) after curative-intent colorectal cancer resection,
Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment Skip to content The CRC Digest ◇ RESEARCH Three Distinct Activity Profiles Identified in CRC Survivors Shortly After Treatment Accelerometer data from 358 colorectal cancer patients revealed three activity profiles: most sedentary (16%), average (53%), and highly active (31%). (J Cancer Surviv) This content is informational only and does not constitute
Phase III trial shows circulating tumor DNA methylation monitoring can guide postoperative surveillance in nonmetastatic colorectal cancer Skip to content The CRC Digest ◆ TRIAL DATA Phase III trial shows circulating tumor DNA methylation monitoring can guide postoperative surveillance in nonmetastatic colorectal cancer The prospective, randomized FIND trial used dynamic ctDNA methylation monitoring to personalize follow-up care after surgery in stage I-III patients. (Journal of Clinical Oncology) This