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surgical

A collection of 21 issues

Updated Guidelines for Resectable Colorectal Cancer Published

Skip to content The CRC Digest ● REGULATORY Updated Guidelines for Resectable Colorectal Cancer Published The American Society of Surgical Oncology summarized contemporary guidance from NCCN, ESMO, and JSCCR, highlighting recent evolution in molecular characterization (including mismatch repair status), neoadjuvant therapy, and organ-preservation strategies. (Ann Surg Oncol) This content is informational

Trimodal prehabilitation studied for anxiety and quality of life in CRC surgery

Skip to content The CRC Digest Trimodal prehabilitation studied for anxiety and quality of life in CRC surgery An interim analysis of 45 patients (20 in prehabilitation, 25 in standard care) in a randomized trial evaluated whether a program combining exercise, nutrition, and psychological counseling could affect perioperative anxiety and

Anastomotic leakage shows minimal long-term impact on quality of life after rectal cancer surgery

Skip to content The CRC Digest ♥ LIVING WITH CRC Anastomotic leakage shows minimal long-term impact on quality of life after rectal cancer surgery A Swedish population-based study found that while anastomotic leakage after anterior resection is associated with long-term bowel dysfunction, its impact on health-related quality of life 3 years

Phase III trial finds no survival benefit from adding chemotherapy to surgery for peritoneal metastases

Skip to content The CRC Digest ◆ TRIAL DATA Phase III trial finds no survival benefit from adding chemotherapy to surgery for peritoneal metastases The CAIRO6 trial (351 patients) found that perioperative systemic therapy did not significantly improve overall survival compared to surgery alone in patients with resectable peritoneal-only metastases (44

Virtual multidisciplinary prehabilitation model developed for CRC surgery patients

Skip to content The CRC Digest Virtual multidisciplinary prehabilitation model developed for CRC surgery patients Researchers developed a standardized virtual model of care for preoperative and postoperative rehabilitation to reduce complications and improve recovery and quality of life. (World Journal of Surgical Oncology) This content is informational only and does

KRAS Mutations Predict Worse Outcomes After Liver Metastasis Surgery

Skip to content The CRC Digest KRAS Mutations Predict Worse Outcomes After Liver Metastasis Surgery In 190 patients who had curative liver surgery for colorectal metastases, KRAS mutations (37.9% of patients) were associated with significantly worse overall and recurrence-free survival and more aggressive recurrence patterns. (Surgery Today) This content

French multicenter study to evaluate ctDNA after liver metastasis surgery

Skip to content The CRC Digest French multicenter study to evaluate ctDNA after liver metastasis surgery The CLIMES PRODIGE 77 study will enroll 232 patients undergoing curative-intent liver metastasis resection to evaluate circulating tumor DNA as a biomarker for detecting minimal residual disease and predicting prognosis. (BMJ Open) This content

Prognostic Factors in Young Patients with Liver Metastases

Skip to content The CRC Digest Prognostic Factors in Young Patients with Liver Metastases A SEER database study of 2,222 patients with colorectal liver metastases compared disease-specific survival in those under 45 versus 45 and older who underwent colon and liver resection from 2010 to 2021. (J Surg Oncol)

Immunotherapy transforms surgical decisions in Lynch syndrome CRC

Skip to content The CRC Digest Immunotherapy transforms surgical decisions in Lynch syndrome CRC Narrative review examines how immune checkpoint inhibitors achieving 60-100% pathological complete response rates in MSI-H/dMMR CRC are challenging traditional recommendations for extensive prophylactic surgery in Lynch syndrome patients. (European Journal of Surgical Oncology) This content

BRAF V600E screening identifies candidates for perioperative therapy

Skip to content The CRC Digest BRAF V600E screening identifies candidates for perioperative therapy Multicenter screening evaluated preoperative BRAF V600E mutation detection in patients with resectable colorectal oligometastases, enabling recruitment to a trial of the BEACON triplet regimen. (Int J Clin Oncol) This content is informational only and does not