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systematic-review

A collection of 36 issues

Review highlights accessible blood-based biomarkers for CRC detection

Skip to content The CRC Digest ◇ RESEARCH Review highlights accessible blood-based biomarkers for CRC detection A systematic review synthesizes circulating transcriptomic and proteomic biomarkers detectable by widely available RT-PCR and ELISA platforms, aiming to bridge the gap between high-throughput research and clinically scalable diagnostics. (Crit Rev Clin Lab Sci) This

Systematic review and meta-analysis quantifies sensitivity and specificity of fecal immunochemical testing and colonoscopy for colorectal cancer screening

Skip to content The CRC Digest ▪ SCREENING Systematic review and meta-analysis quantifies sensitivity and specificity of fecal immunochemical testing and colonoscopy for colorectal cancer screening Researchers analyzed multiple studies to estimate the accuracy of two major screening tests in asymptomatic average-risk adults. (Preventive Medicine Reports) This content is informational only

CRC Research Finding

Skip to content The CRC Digest ◇ Review examines anti-VEGF plus checkpoint inhibitor combinations in GI cancers A narrative review synthesizes preclinical and clinical data on combining anti-VEGF agents with immune checkpoint inhibitors across gastrointestinal cancers, including colorectal cancer, with emphasis on optimal sequencing strategies. (Discov Oncol) This content is informational

Review examines immune checkpoint inhibitors in dMMR-MSI-H CRC

Skip to content The CRC Digest Review examines immune checkpoint inhibitors in dMMR-MSI-H CRC Comprehensive review discusses the immunological basis for exceptional responsiveness to PD-1 and CTLA-4 inhibitors in dMMR-MSI-H colorectal cancer, along with emerging resistance mechanisms and predictive biomarkers. (Front Immunol) This content is informational only and does not

CRC Research Finding

Skip to content The CRC Digest ◇ Systematic review examines Fusobacterium nucleatum as predictor of treatment response A systematic review evaluated whether Fusobacterium nucleatum, a bacterium implicated in CRC progression and immune modulation, can predict treatment response, though its role as a biomarker remains unclear. (Cancer Treatment Reviews) This content is

Review examines liquid biopsy potential and limitations for CRC screening

Skip to content The CRC Digest Review examines liquid biopsy potential and limitations for CRC screening Analysis notes promise of circulating tumor DNA and cells for detection but highlights limited sensitivity for advanced adenomas and lack of randomized trial evidence for mortality reduction. (Intestinal Research) This content is informational only

Lynch syndrome prevalence varies by population and cancer type

Skip to content The CRC Digest Lynch syndrome prevalence varies by population and cancer type A review of published studies found Lynch syndrome prevalence ranges from 0.7% to 4% among unselected colorectal cancer patients, with higher rates in selected high-risk patients and up to 5.9% in Canadian endometrial

MiR-31 as Predictive Biomarker for Cetuximab Response

Skip to content The CRC Digest MiR-31 as Predictive Biomarker for Cetuximab Response A systematic review evaluated microRNA-31 (miR-31-3p and miR-31-5p) as a potential predictive biomarker for cetuximab efficacy in metastatic CRC, even among RAS wild-type patients where response variability remains high. (Clin Transl Oncol) This content is informational only

CRC Research Finding

Skip to content The CRC Digest ♥ Review identifies gaps in measuring patient experience during surveillance colonoscopy A scoping review found no standard set of patient-reported outcomes or measures for individuals undergoing regular surveillance colonoscopy, despite guidelines recommending these assessments as quality indicators. (Quality of Life Research) This content is informational

CRC Research Finding

Skip to content The CRC Digest ▪ Methylation Biomarkers Show High Sensitivity for Colorectal Cancer Detection The Cologuard assay demonstrates 92% sensitivity for detecting colorectal cancer, both outperforming traditional screening methods through DNA methylation detection. (J Cancer Res Ther) This content is informational only and does not constitute medical advice. Always