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Alex Chompff

Targeted m6A Demethylation of ZBTB7A Suppresses Liver Metastasis in Preclinical Models

Skip to content The CRC Digest Targeted m6A Demethylation of ZBTB7A Suppresses Liver Metastasis in Preclinical Models Researchers identified ZBTB7A as an m6A-modified transcription factor that promotes colorectal cancer liver metastasis, with METTL3-mediated m6A modification of ZBTB7A facilitating recognition by the m6A reader YTHDF1/3 complex. (Molecular Cancer) This content

Real-World Study Characterizes Colorectal Neoplasia in Adults Under 50

Skip to content The CRC Digest Real-World Study Characterizes Colorectal Neoplasia in Adults Under 50 A single-center study of 152 patients aged 18-49 who underwent colonoscopy between 2018 and 2023 characterized the clinical, anatomical, and histopathological features of colorectal lesions in younger adults. (Journal of Clinical Medicine) This content is

Fusobacterium nucleatum Detected in 11% of Adenomas, Linked to Immune Signatures

Skip to content The CRC Digest ◇ RESEARCH Fusobacterium nucleatum Detected in 11% of Adenomas, Linked to Immune Signatures RNA-based detection found Fusobacterium nucleatum in 11% of adenoma tissue samples, with positive patients exhibiting enriched anti-bacterial defense response and immune-related transcriptomic signatures compared to negative patients. (International Journal of Molecular Sciences)

Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy

Skip to content The CRC Digest ▪ SCREENING Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy A retrospective study of 800 adults from a US health-system biobank who underwent colonoscopy between 2010 and 2025 found that inherited genetic risk may improve yield of adenoma detection and prioritization of colonoscopy

Blood Test Combining cfDNA Fragmentomics and Methylation Markers Detects Precancerous Lesions

Skip to content The CRC Digest ▪ SCREENING Blood Test Combining cfDNA Fragmentomics and Methylation Markers Detects Precancerous Lesions A study of 380 CRC patients, 121 individuals with precancerous lesions, and 506 healthy controls found that adding methylation analysis of SEPT9 and HS3ST2 to cfDNA fragmentomic features improved detection of precancerous

Final Analysis of DEEPER Trial Shows No Survival Difference Between Cetuximab and Bevacizumab in RAS/BRAF Wild-Type mCRC

Skip to content The CRC Digest ◆ TRIAL DATA Final Analysis of DEEPER Trial Shows No Survival Difference Between Cetuximab and Bevacizumab in RAS/BRAF Wild-Type mCRC The phase II DEEPER trial found no differences in progression-free survival or overall survival in the per-protocol set when comparing modified-FOLFOXIRI plus cetuximab versus

CRC Research Update — August 27, 2026

Today's colorectal cancer research highlights

Oncogenic KRAS and BRAF Drive Lactate-Mediated Immune Suppression in Microsatellite-Stable CRC

Skip to content The CRC Digest ◇ RESEARCH Oncogenic KRAS and BRAF Drive Lactate-Mediated Immune Suppression in Microsatellite-Stable CRC A mechanistic review describes how KRAS and BRAF mutations drive aerobic glycolysis and lactate accumulation, which suppresses T-cell function and contributes to immunotherapy resistance in MSS tumors. (Int J Mol Sci) This

Kazakhstan Study Links KRAS Mutation Detection Methods to Survival in Stage II-IV CRC

Skip to content The CRC Digest ◇ RESEARCH Kazakhstan Study Links KRAS Mutation Detection Methods to Survival in Stage II-IV CRC A 332-patient cohort study compared KRAS variant detection by real-time and digital PCR in tumor tissue and plasma, examining associations with overall survival across stage II-IV disease. (Genes) This content

Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort

Skip to content The CRC Digest ◇ RESEARCH Lynch Syndrome Screening Performance Assessed in Early-Onset CRC Cohort The Padua study specifically evaluated mismatch repair testing and Lynch syndrome detection in early-onset CRC patients as part of a universal screening approach. (Cancers) This content is informational only and does not constitute medical