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Alex Chompff

Phase II trial examines quality of life with panitumumab-based intensified regimen

Skip to content The CRC Digest Phase II trial examines quality of life with panitumumab-based intensified regimen The VOLFI trial analyzed health-related quality of life in patients with RAS wild-type metastatic colorectal cancer treated with mFOLFOXIRI plus panitumumab versus FOLFOXIRI, noting that anti-EGFR antibodies like panitumumab are associated with a

Screening strategies may not adequately address early-onset CRC burden

Skip to content The CRC Digest Screening strategies may not adequately address early-onset CRC burden A systematic review found uncertainty remains regarding whether current screening strategies adequately address the diagnostic burden of early-onset colorectal cancer, defined as diagnosis before age 50. (Cancer Epidemiol) This content is informational only and does

Study identifies FAIM2 pathway in cancer-associated fibroblasts linked to immune resistance in MSS colorectal cancer

Skip to content The CRC Digest ◇ RESEARCH Study identifies FAIM2 pathway in cancer-associated fibroblasts linked to immune resistance in MSS colorectal cancer Researchers identified Fas apoptotic inhibitory molecule 2 (FAIM2) as a stromal regulator downregulated in microsatellite-stable colorectal cancer, where it inversely correlates with collagen production in cancer-associated fibroblasts and

Phase 1 trial evaluates oral KRAS G12D inhibitor GFH375 in advanced solid tumors

Skip to content The CRC Digest ▸ TREATMENT Phase 1 trial evaluates oral KRAS G12D inhibitor GFH375 in advanced solid tumors A phase 1 dose-escalation trial evaluated GFH375, an oral compound that targets both active and inactive states of KRAS G12D proteins, in patients with advanced solid tumors harboring the KRAS

Meta-analysis shows ctDNA after surgery strongly predicts recurrence risk

Skip to content The CRC Digest ◇ RESEARCH Meta-analysis shows ctDNA after surgery strongly predicts recurrence risk A meta-analysis of seven prospective cohorts found that postoperative circulating tumor DNA positivity was associated with increased recurrence risk (pooled hazard ratio, 7.60; 95% CI, 4.70-12.31) after curative-intent colorectal cancer resection,

Systematic review finds screening gaps in early-onset colorectal cancer despite lowered age thresholds

Skip to content The CRC Digest ▪ SCREENING Systematic review finds screening gaps in early-onset colorectal cancer despite lowered age thresholds A systematic review of population-based screening studies found that current strategies may not adequately address the diagnostic burden of colorectal cancer in adults younger than 50, even as several countries

CRC Research Update — September 15, 2026

Today's colorectal cancer research highlights

Review examines why microsatellite-stable tumors resist immunotherapy

Skip to content The CRC Digest ◇ RESEARCH Review examines why microsatellite-stable tumors resist immunotherapy A systematic review found that mismatch repair-proficient, microsatellite stable tumors remain resistant to immunotherapy due to low neoantigen load, defects in antigen presentation, and Wnt/β-catenin pathway activity that reduce immune recognition and T-cell infiltration. (Molecules)

AI algorithm stratifies stage II/IIIA colorectal cancer recurrence risk from standard pathology slides

Skip to content The CRC Digest ◇ RESEARCH AI algorithm stratifies stage II/IIIA colorectal cancer recurrence risk from standard pathology slides HistoNav, a deep-learning algorithm analyzing H&E-stained tissue samples from 2,095 patients, identified low-, intermediate-, and high-risk groups with 5-year disease-specific survival rates of 93.2%, 84.

AI-assisted colonoscopy systems standardize polyp detection accuracy

Skip to content The CRC Digest ▪ SCREENING AI-assisted colonoscopy systems standardize polyp detection accuracy Computer-aided detection and diagnosis systems using deep learning convolutional neural networks reduce inter-operator variability in adenoma detection rates and help identify diminutive and morphologically subtle lesions. (Journal of Clinical Medicine) This content is informational only and