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Alex Chompff

New FAK inhibitor shows promise in KRAS-mutant colorectal cancer

Skip to content The CRC Digest New FAK inhibitor shows promise in KRAS-mutant colorectal cancer Researchers designed a focal adhesion kinase (FAK) inhibitor (compound 7g) that demonstrated antiproliferative activity in KRAS-mutant HCT116 colorectal cancer cells and showed 66.5% tumor growth inhibition in mouse models. (Bioorg Chem) This content is

CRC Research Finding

Skip to content The CRC Digest ◇ Mismatch repair-deficient CRC with bowel obstruction shows excellent response to immunotherapy A case series reports that patients with mismatch repair-deficient (dMMR) colorectal cancer presenting with bowel obstruction achieved excellent responses to immunotherapy. (Annals of Coloproctology) This content is informational only and does not constitute

CRC Research Update — July 02, 2026

Today's colorectal cancer research highlights

KRAS Mutations Predict Worse Outcomes After Liver Metastasis Surgery

Skip to content The CRC Digest KRAS Mutations Predict Worse Outcomes After Liver Metastasis Surgery In 190 patients who had curative liver surgery for colorectal metastases, KRAS mutations (37.9% of patients) were associated with significantly worse overall and recurrence-free survival and more aggressive recurrence patterns. (Surgery Today) This content

Early-Onset CRC Rising Across Europe with Regional Disparities

Skip to content The CRC Digest Early-Onset CRC Rising Across Europe with Regional Disparities Incidence of colorectal cancer in people under 50 is rising across Europe, with stark regional differences in incidence and mortality; early-onset disease shows a predominance for distal tumors and aggressive features. (European Journal of Cancer) This

CRC Research Finding

Skip to content The CRC Digest ▪ Personalized ctDNA Test Detects Stage III Recurrence Before Imaging A case series of four stage III CRC patients showed the Signatera ctDNA assay detected recurrence earlier than imaging and informed curative interventions. (Cancer Diagnosis & Prognosis) This content is informational only and does not

CRC Research Update — July 01, 2026

Today's colorectal cancer research highlights

Prehabilitation study evaluates exercise and nutrition before GI cancer surgery

Skip to content The CRC Digest Prehabilitation study evaluates exercise and nutrition before GI cancer surgery A prospective controlled trial evaluates the feasibility, safety, and preliminary effectiveness of supervised moderate-to-high intensity exercise combined with nutritional counseling in gastrointestinal cancer patients scheduled for surgery. (BMC Cancer) This content is informational only

Cross-kingdom gut microbiome model predicts colorectal adenomas

Skip to content The CRC Digest Cross-kingdom gut microbiome model predicts colorectal adenomas Researchers analyzed 296 fecal samples using metagenomic sequencing and developed a predictive model incorporating bacteria, viruses, archaea, and fungi to identify colorectal adenomas, the main precancerous lesion. (Front Microbiol) This content is informational only and does not

French multicenter study to evaluate ctDNA after liver metastasis surgery

Skip to content The CRC Digest French multicenter study to evaluate ctDNA after liver metastasis surgery The CLIMES PRODIGE 77 study will enroll 232 patients undergoing curative-intent liver metastasis resection to evaluate circulating tumor DNA as a biomarker for detecting minimal residual disease and predicting prognosis. (BMJ Open) This content