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early-onset

A collection of 186 issues

Hypothesis-generating study explores potential association between intensive long-distance running and advanced adenomas in runners aged 35–50

Skip to content The CRC Digest Hypothesis-generating study explores potential association between intensive long-distance running and advanced adenomas in runners aged 35–50 A prospective study of 100 participants who completed at least five marathons or two ultramarathons explored a potential association between intensive long-distance running and advanced adenomas of

CRC Research Update — October 20, 2026

Today's colorectal cancer research highlights

16-year-old with MSI-H CRC remains disease-free 5+ years after adjuvant FOLFOX

Skip to content The CRC Digest 16-year-old with MSI-H CRC remains disease-free 5+ years after adjuvant FOLFOX A 16-year-old male with mucinous adenocarcinoma (pT4N0M0) showing loss of MSH2/MSH6 expression received 12 cycles of adjuvant FOLFOX chemotherapy and remains disease-free more than 5 years after completion of therapy. (Am J

CRC Research Update — October 17, 2026

Today's colorectal cancer research highlights

Colorectal neoplasia detected at young age in Li-Fraumeni syndrome surveillance

Skip to content The CRC Digest ▪ SCREENING Colorectal neoplasia detected at young age in Li-Fraumeni syndrome surveillance In seven women with Li-Fraumeni syndrome, colorectal neoplasia was detected in five patients at a median age of 32.5 years, including one colorectal cancer at age 32 and three advanced adenomas; four

CRC Research Update — October 16, 2026

Today's colorectal cancer research highlights

Younger Patients Show Higher TP53 and SMAD4 Mutations

Skip to content The CRC Digest Younger Patients Show Higher TP53 and SMAD4 Mutations Meta-analysis of 43 studies found early-onset CRC has higher TP53 and SMAD4 mutation frequencies and lower APC and KRAS mutations, highlighting distinct molecular pathways in younger adults. (Cancers) This content is informational only and does not

Early-Onset CRC Shows Distinct Mutation Profile in Meta-Analysis of 154,982 Patients

Skip to content The CRC Digest ◇ RESEARCH Early-Onset CRC Shows Distinct Mutation Profile in Meta-Analysis of 154,982 Patients A systematic review found that colorectal cancer diagnosed before age 50 has higher frequencies of TP53 and SMAD4 mutations and lower frequencies of APC, KRAS, and BRAF mutations compared to late-onset

CRC Research Update — October 15, 2026

Today's colorectal cancer research highlights

Nomogram predicts survival in early-onset colorectal cancer using routine lab markers

Skip to content The CRC Digest Nomogram predicts survival in early-onset colorectal cancer using routine lab markers A prognostic model incorporating T/N stage, tumor markers, and systemic immune-inflammation index achieved 3-year survival prediction AUCs of 0.897 in training and 0.861 in external validation cohorts of 410 patients