Oral TKI anlotinib shows non-inferiority to bevacizumab plus chemotherapy in first-line RAS/BRAF wild-type metastatic colorectal cancer Skip to content The CRC Digest ◆ TRIAL DATA Oral TKI anlotinib shows non-inferiority to bevacizumab plus chemotherapy in first-line RAS/BRAF wild-type metastatic colorectal cancer The phase 3 ANCHOR trial (NCT04854668) compared CapeOX chemotherapy combined with anlotinib versus CapeOX combined with bevacizumab in patients with RAS/BRAF wild-type mCRC, evaluating
Plant-derived formulation disrupts metabolism in KRAS-mutant colorectal and pancreatic cancer cells Skip to content The CRC Digest Plant-derived formulation disrupts metabolism in KRAS-mutant colorectal and pancreatic cancer cells A Lepidium latifolium formulation induced cell death and metabolic disruption in KRAS-mutant cancer models through iron-dependent mechanisms. (Molecules) This content is informational only and does not constitute medical advice. Always consult your oncologist
Kazakhstan Study Links KRAS Mutation Detection Methods to Survival in Stage II-IV CRC Skip to content The CRC Digest ◇ RESEARCH Kazakhstan Study Links KRAS Mutation Detection Methods to Survival in Stage II-IV CRC A 332-patient cohort study compared KRAS variant detection by real-time and digital PCR in tumor tissue and plasma, examining associations with overall survival across stage II-IV disease. (Genes) This content
Kazakhstani pilot study profiles KRAS and BRAF mutations using NGS and ddPCR Skip to content The CRC Digest Kazakhstani pilot study profiles KRAS and BRAF mutations using NGS and ddPCR Researchers used targeted next-generation sequencing and droplet digital PCR to characterize KRAS and BRAF mutations in metastatic colorectal cancer patients from Kazakhstan, where molecular epidemiological data remain limited. (Frontiers in Medicine) This
Disrupting KRAS-AGO2 interaction may sensitize KRAS-mutant CRC to therapy Skip to content The CRC Digest Disrupting KRAS-AGO2 interaction may sensitize KRAS-mutant CRC to therapy Preclinical research developed peptide-gold nanoparticles that disrupt the interaction between mutated KRAS and AGO2, potentially sensitizing KRAS-mutated colorectal cancer to chemo-immunotherapy. (Apoptosis) This content is informational only and does not constitute medical advice. Always consult