CRC Research Finding Skip to content The CRC Digest ◇ Single-cell analysis identifies epithelial cell fate signature predicting liver metastasis risk Researchers integrated single-cell RNA sequencing of paired liver metastasis tissues to define an epithelial cell fate gene signature, then projected it onto 433 primary CRC cases to establish a predictive model for liver
ABFOLFOX neoadjuvant therapy studied in unresectable liver metastases Skip to content The CRC Digest ◆ TRIAL DATA ABFOLFOX neoadjuvant therapy studied in unresectable liver metastases — Genome Medicine A study examined neoadjuvant ABFOLFOX (atezolizumab, bevacizumab, leucovorin, 5-fluorouracil, and oxaliplatin) in patients with unresectable colorectal liver metastases. The research explored molecular dynamics of tumor ecosystems and their impact on treatment outcomes.
Blood-Based ctDNA Testing May Help Monitor for Cancer Return After Surgery Skip to content The CRC Digest Blood-Based ctDNA Testing May Help Monitor for Cancer Return After Surgery Meta-analysis supports use of circulating tumor DNA as a biomarker to detect recurrence risk in patients who had liver metastases surgically removed. (Clinical Colorectal Cancer) This content is informational only and does not