Liquid biopsy detects residual disease after oligometastasis surgery Skip to content The CRC Digest ▪ SCREENING Liquid biopsy detects residual disease after oligometastasis surgery A prospective multicenter study of 118 patients with resectable colorectal oligometastases found that combining pretreatment circulating tumor DNA genomic profiling with post-operative molecular residual disease (MRD) detection identified patients at highest risk of recurrence, with
Recurrence drives long-term prognosis after liver metastasis resection Skip to content The CRC Digest ◆ TRIAL DATA Recurrence drives long-term prognosis after liver metastasis resection An international study of 3,002 patients who underwent hepatectomy for colorectal liver metastases found that 54% developed recurrence; multistate modeling showed that the probability of recurrence decreased the longer patients remained recurrence-free, and
Liver metastases amplify immune resistance in MSS colorectal cancer Skip to content The CRC Digest Liver metastases amplify immune resistance in MSS colorectal cancer Across early-phase and retrospective studies, responses to checkpoint-based combinations have been observed more often in patients without active liver metastases in microsatellite-stable colorectal cancer. (Frontiers in Immunology) This content is informational only and does not
French trial tests reintroducing chemotherapy after liver metastasis resection Skip to content The CRC Digest ▸ TREATMENT French trial tests reintroducing chemotherapy after liver metastasis resection The IRIMAD phase III trial is randomizing patients who responded well to preoperative FOLFIRI and underwent curative resection of metachronous colorectal liver metastases to postoperative FOLFIRI reintroduction in the experimental arm. (Dig Liver Dis)