SPP1+ macrophages linked to chemotherapy resistance in colorectal liver metastasis Skip to content The CRC Digest ◇ RESEARCH SPP1+ macrophages linked to chemotherapy resistance in colorectal liver metastasis Single-cell RNA sequencing identified a macrophage subpopulation marked by elevated SPP1 expression that is significantly enriched in patients who respond insufficiently to neoadjuvant chemotherapy; these cells suppress CD8+ T cell function through the
TIGIT+ CD4+ T Cells in Liver Metastases Linked to Shorter Survival Skip to content The CRC Digest ◇ RESEARCH TIGIT+ CD4+ T Cells in Liver Metastases Linked to Shorter Survival Flow cytometric profiling of 17 patients undergoing liver metastasectomy found that enrichment of TIGIT+ CD4+ T cells in colorectal cancer liver metastases was associated with shorter overall survival, highlighting differences in the
Aspirin after liver metastasis treatment tested in phase 3 trial Skip to content The CRC Digest ◆ TRIAL DATA Aspirin after liver metastasis treatment tested in phase 3 trial The ASAC trial randomly assigned patients who had undergone curative-intent treatment for colorectal cancer liver metastases to aspirin or placebo to assess whether adjuvant aspirin improves disease-free survival. (Lancet Gastroenterol Hepatol) This
Review Examines Immunotherapy in Liver Metastases Beyond MMR Status Skip to content The CRC Digest ◇ RESEARCH Review Examines Immunotherapy in Liver Metastases Beyond MMR Status A review explored immunotherapy approaches in colorectal cancer liver metastases, examining the hepatic metastatic niche beyond traditional mismatch repair considerations. (Frontiers in Immunology) This content is informational only and does not constitute medical advice.