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meta-analysis

A collection of 23 issues

Meta-analysis examines timing of chemotherapy after colorectal cancer surgery

Skip to content The CRC Digest ◆ TRIAL DATA Meta-analysis examines timing of chemotherapy after colorectal cancer surgery A systematic review and meta-analysis evaluated the impact of early versus delayed postoperative chemotherapy on overall survival in colorectal cancer patients, aiming to guide clinical decisions on optimal chemotherapy timing. (J Gastrointest Cancer)

Endocrine side effects vary by immunotherapy regimen in CRC

Skip to content The CRC Digest Endocrine side effects vary by immunotherapy regimen in CRC A network meta-analysis of six randomized trials found that pembrolizumab and ICI plus tyrosine kinase inhibitor combinations significantly increased hypothyroidism risk, while hyperthyroidism was higher with ICI-TKI and ICI-chemotherapy-antiangiogenic regimens. (Frontiers in Immunology) This content

RAS and BRAF mutations may predict different immunotherapy outcomes in MSI-H/dMMR metastatic CRC

Skip to content The CRC Digest ◇ RESEARCH RAS and BRAF mutations may predict different immunotherapy outcomes in MSI-H/dMMR metastatic CRC A meta-analysis found that oncogenic driver mutations like RAS and BRAF may contribute to clinically meaningful differences in how MSI-H/dMMR metastatic colorectal cancer responds to immune checkpoint inhibitors,

First-line immunotherapy outperforms chemotherapy in MSI-H/dMMR metastatic colorectal cancer

Skip to content The CRC Digest ◆ TRIAL DATA First-line immunotherapy outperforms chemotherapy in MSI-H/dMMR metastatic colorectal cancer A meta-analysis of phase III trials confirms immune checkpoint inhibitors show superior progression-free and overall survival compared to standard chemotherapy as first-line treatment for patients with MSI-H or dMMR metastatic disease. (J

Systematic review and meta-analysis quantifies sensitivity and specificity of fecal immunochemical testing and colonoscopy for colorectal cancer screening

Skip to content The CRC Digest ▪ SCREENING Systematic review and meta-analysis quantifies sensitivity and specificity of fecal immunochemical testing and colonoscopy for colorectal cancer screening Researchers analyzed multiple studies to estimate the accuracy of two major screening tests in asymptomatic average-risk adults. (Preventive Medicine Reports) This content is informational only

Meta-analysis projects rising early-onset CRC burden through 2030

Skip to content The CRC Digest Meta-analysis projects rising early-onset CRC burden through 2030 A systematic review and meta-analysis evaluated early-onset colorectal cancer (diagnosed under age 50) incidence and temporal trends from 1990 to 2021, identifying associated risk factors and projecting burden through 2030. (Cureus) This content is informational only

CRC Research Finding

Skip to content The CRC Digest ▸ Meta-Analysis Confirms Targeted Therapy Benefits for Colorectal Cancer Liver Metastases A systematic review and meta-analysis evaluated targeted therapy in colorectal cancer liver metastases, examining overall survival, progression-free survival, objective response rate, and conversion to resection. The analysis provides comprehensive evidence on the role of

CRC Research Finding

Skip to content The CRC Digest ▸ Meta-Analysis Compares TAS-102 and Regorafenib Sequencing in Later-Line mCRC A systematic review and meta-analysis compared efficacy and safety of TAS-102 followed by regorafenib versus the reverse sequence in patients with metastatic colorectal cancer who had previously failed chemotherapy. (Chin Clin Oncol) This content is

AI-assisted colonoscopy improves adenoma detection

Skip to content The CRC Digest AI-assisted colonoscopy improves adenoma detection Meta-analysis of 42 studies confirms AI assistance during colonoscopy improves detection of precancerous polyps. (JCO) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC Digest — crcdigest.com

CRC Research Finding

Skip to content The CRC Digest ▸ Cetuximab Maintenance Therapy Evaluated in Meta-Analysis A systematic review and meta-analysis assessed the efficacy and safety of cetuximab maintenance therapy in metastatic colorectal cancer, pooling data on progression-free survival, overall survival, and adverse effects through March 2026. (Front Pharmacol) This content is informational only