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under-50

A collection of 94 issues

Hospitalization outcomes differ between early- and late-onset CRC patients

Skip to content The CRC Digest Hospitalization outcomes differ between early- and late-onset CRC patients A national database study (2016-2020) compared hospitalization trends and outcomes in patients diagnosed before age 50 versus those 50 and older, finding distinct patterns in mortality, length of stay, and associations with obesity and sociodemographic

Dietary and metabolic risk factors drive rising early-onset CRC rates in the U.S.

Skip to content The CRC Digest ♥ LIVING WITH CRC Dietary and metabolic risk factors drive rising early-onset CRC rates in the U.S. A 33-year analysis of Global Burden of Disease data shows that while traditional colorectal cancer rates in older adults have declined, early-onset cases (diagnosed under age 50)

CRC Research Update — September 06, 2026

Today's colorectal cancer research highlights

CRC burden rising fastest in adults under 50

Skip to content The CRC Digest ▪ SCREENING CRC burden rising fastest in adults under 50 Analysis of GBD 2023 data found CRC incidence rose most in adults aged 15-44 (+16.8%). (Annals of Medicine) This content is informational only and does not constitute medical advice. Always consult your oncologist or

Calcitriol Modulates Age-Dependent Drug Response in Patient-Derived Colorectal Organoids

Skip to content The CRC Digest Calcitriol Modulates Age-Dependent Drug Response in Patient-Derived Colorectal Organoids Researchers used paired patient-derived normal and tumor colorectal organoids to investigate how calcitriol (the active vitamin D metabolite) modulates chemotherapy response. Dose-response analyses revealed marked interpatient variability, with SN38 being more potent than 5-fluorouracil and

Age-Stratified Mutation Patterns Reveal Distinct Features in Early-Onset CRC

Skip to content The CRC Digest ◇ RESEARCH Age-Stratified Mutation Patterns Reveal Distinct Features in Early-Onset CRC Analysis of 6,762 samples across four age groups found that early-onset colorectal cancer (diagnosed before age 50) shows different mutation patterns compared to later-onset disease, with implications for testing guidelines and therapeutic development.

CRC Research Update — September 04, 2026

Today's colorectal cancer research highlights

Vietnamese Cohort Compares Early- vs Late-Onset CRC Outcomes

Skip to content The CRC Digest Vietnamese Cohort Compares Early- vs Late-Onset CRC Outcomes A retrospective study of 486 patients who underwent curative resection in Vietnam's Mekong Delta compared clinicopathologic features and survival between early-onset and late-onset colorectal cancer. (Arq Bras Cir Dig) This content is informational only

Early-Onset Colorectal Cancer Incidence Accelerates Through 2023

Skip to content The CRC Digest ▪ SCREENING Early-Onset Colorectal Cancer Incidence Accelerates Through 2023 SEER data show early-onset CRC incidence accelerated during 2019-2023 with an annual percent change of 8.3%, while incidence among adults 65 and older declined. Black patients more often presented with stage IV disease (33.9%

CRC Research Update — September 03, 2026

Today's colorectal cancer research highlights