CRC Research Update — April 21, 2026
Today's colorectal cancer research highlights
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Epigenetic analysis reveals pesticide link to early-onset disease
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The CRC Digest
Epigenetic analysis reveals pesticide link to early-onset disease
Methylation risk scores identified picloram herbicide exposure as significantly associated with CRC diagnosed before age 50 compared to patients 70 and older. (Nature Medicine)
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CRC Research Finding
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The CRC Digest
▸ Biomimetic nanoparticles enhance checkpoint blockade by remodeling tumor stiffness
Platelet membrane-coated nanoparticles carrying Defactinib and PD-L1 antibodies reduced tumor matrix rigidity and improved immune cell infiltration in preclinical CRC models, suggesting a strategy to overcome checkpoint inhibitor resistance. (Journal of Nanobiotechnology)
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CRC Research Update — April 20, 2026
Today's colorectal cancer research highlights
Blood-Based ctDNA Testing May Help Monitor for Cancer Return After Surgery
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The CRC Digest
Blood-Based ctDNA Testing May Help Monitor for Cancer Return After Surgery
Meta-analysis supports use of circulating tumor DNA as a biomarker to detect recurrence risk in patients who had liver metastases surgically removed. (Clinical Colorectal Cancer)
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Case Series Reports Bowel Narrowing as Rare Side Effect of Immunotherapy
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The CRC Digest
Case Series Reports Bowel Narrowing as Rare Side Effect of Immunotherapy
Doctors report cases of bowel stenosis (narrowing) in dMMR colorectal cancer patients treated with immunotherapy, a side effect that clinicians should monitor. (Clinical Colorectal Cancer)
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Patients Describe Complex Impact of Chemo Brain on Daily Life
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The CRC Digest
Patients Describe Complex Impact of Chemo Brain on Daily Life
Qualitative study identifies how cognitive impairment from chemotherapy affects memory, concentration, and emotional health in colorectal cancer patients. (Journal of Health Psychology)
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CRC Research Finding
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The CRC Digest
♥ Study Explores Patients' Experiences with Chemotherapy-Related Cognitive Impairment
Interviews with 12 colorectal cancer patients revealed how chemotherapy affects cognitive abilities, emotional well-being, and daily functioning. (Journal of Health Psychology)
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CRC Research Update — April 19, 2026
Today's colorectal cancer research highlights
Blood-Based Screening Biomarkers Under Review
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The CRC Digest
Blood-Based Screening Biomarkers Under Review
Researchers identified novel blood test candidates that could complement or enhance current colorectal cancer screening approaches. (Clinical Colorectal Cancer)
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© 2026 The
ctDNA Among Novel Screening Biomarkers
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The CRC Digest
ctDNA Among Novel Screening Biomarkers
Systematic review highlights circulating tumor DNA as a candidate for blood-based colorectal cancer screening. (Clinical Colorectal Cancer)
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© 2026 The CRC Digest
AI-Based MSI Detection Shows Promise
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The CRC Digest
AI-Based MSI Detection Shows Promise
Meta-analysis confirms deep learning tools can accurately identify MSI-H status, which determines eligibility for immunotherapy. (Clinical Colorectal Cancer)
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© 2026 The CRC
CRC Research Finding
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The CRC Digest
▪ Review Identifies Promising Blood-Based Biomarkers for CRC Screening
A systematic review examined novel blood tests, including circulating tumor DNA (ctDNA), that could help detect colorectal cancer and precancerous conditions earlier through less invasive screening methods. (Clinical Colorectal Cancer)
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This Week in CRC Research — April 19, 2026
Weekly colorectal cancer research intelligence
FIERCE Study: Trifluridine/Tipiracil With Radiation in Rectal Cancer
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The CRC Digest
FIERCE Study: Trifluridine/Tipiracil With Radiation in Rectal Cancer — Clinical Colorectal Cancer
Results from the FIERCE study have been published in Clinical Colorectal Cancer.
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© 2026 The
Phase II: Pembrolizumab Plus Capecitabine and Bevacizumab in MSS Metastatic CRC
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The CRC Digest
Phase II: Pembrolizumab Plus Capecitabine and Bevacizumab in MSS Metastatic CRC — Clinical Colorectal Cancer
Clinical Colorectal Cancer.
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© 2026 The CRC Digest —
crcdigest.com
AZUR-4: Neoadjuvant Dostarlimab Plus Chemotherapy in MSS Colon Cancer
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The CRC Digest
AZUR-4: Neoadjuvant Dostarlimab Plus Chemotherapy in MSS Colon Cancer — Clinical Colorectal Cancer
The AZUR-4 trial protocol has been published in Clinical Colorectal Cancer.
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© 2026 The CRC
Long-Term Results: Adjuvant Chemotherapy After Liver Metastasis Surgery (JCOG0603)
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The CRC Digest
Long-Term Results: Adjuvant Chemotherapy After Liver Metastasis Surgery (JCOG0603) — Journal of Clinical Oncology
Journal of Clinical Oncology.
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© 2026 The CRC Digest —
crcdigest.com
Circulating Tumor DNA Testing May Increase Fear of Recurrence in Some Colorectal Cancer Survivors
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The CRC Digest
♥ LIVING WITH CRC
Circulating Tumor DNA Testing May Increase Fear of Recurrence in Some Colorectal Cancer Survivors — Psycho-Oncology
Researchers interviewed colorectal cancer survivors enrolled in the DYNAMIC trials, which used ctDNA testing to guide decisions about adjuvant chemotherapy after surgery. While many patients valued
HER2 Amplification May Predict Resistance to Anti-EGFR Therapy in Metastatic Colorectal Cancer
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The CRC Digest
▸ TREATMENT
HER2 Amplification May Predict Resistance to Anti-EGFR Therapy in Metastatic Colorectal Cancer — ESMO Gastrointestinal Oncology
An exploratory analysis from the CAPRI-2 GOIM trial examined HER2 gene alterations in patients with RAS/BRAF wild-type, microsatellite stable metastatic colorectal cancer treated with FOLFIRI chemotherapy plus