Archive

Today's colorectal cancer research highlights

Skip to content The CRC Digest Immune Recovery After Surgery Linked to ctDNA Minimal Residual Disease A prospective study of 1,000 stage II-III CRC patients found that distinct perioperative immunocircadian recovery trajectories were associated with postoperative ctDNA-based minimal residual disease and long-term survival outcomes. (Surgery) This content is informational

Skip to content The CRC Digest ♥ LIVING WITH CRC Biological Age and Neighborhood Deprivation Linked to Psychological Distress During Chemotherapy An analysis of 958 adults with stage II-III CRC receiving chemotherapy found that biological age and neighborhood deprivation predict depression and anxiety symptoms, highlighting biosocial factors that may influence mental

Skip to content The CRC Digest ◇ RESEARCH Circulating Tumor DNA Predicts Recurrence After Liver Metastasis Resection A systematic review and meta-analysis found that circulating tumor DNA (ctDNA) serves as a biomarker for recurrence after curative resection of colorectal cancer liver metastases, potentially guiding post-surgical surveillance strategies. (Clinical Colorectal Cancer) This

Skip to content The CRC Digest ◇ RESEARCH KRAS Mutation Enriches Gut Bacteria Linked to Tumor Growth A study in KRAS-mutant CRC patients and mice found that KRAS reshapes the microbial community, enriching Bacteroides acidifaciens, which predicts poor prognosis and promotes malignant phenotypes in KRAS-mutant tumors. (Cell Host & Microbe) This

Skip to content The CRC Digest ◇ RESEARCH Multigene Panel Testing Yield Quantified in Colorectal Cancer Patients A systematic review and meta-analysis examined the diagnostic yield of germline multigene panel testing using next-generation sequencing in unselected patients with colorectal cancer, helping clarify how often inherited genetic factors contribute to diagnosis. (Lancet

Skip to content The CRC Digest ▪ SCREENING AI Tool Shows Promise for Scalable Colorectal Cancer Screening Researchers describe progress toward practical artificial intelligence applications that could expand access to colorectal cancer screening at scale. (Annals of Oncology) This content is informational only and does not constitute medical advice. Always consult

Skip to content The CRC Digest Developing Quality Programs to Track Colorectal Cancer Screening A new article proposes features for an ideal tracking system to enhance screening program performance, noting that common issues include suboptimal return rates for stool-based tests, lack of timely colonoscopy after abnormal results, and surveillance recommendations

Skip to content The CRC Digest Calcitriol Modulates Age-Dependent Drug Response in Patient-Derived Colorectal Organoids Researchers used paired patient-derived normal and tumor colorectal organoids to investigate how calcitriol (the active vitamin D metabolite) modulates chemotherapy response. Dose-response analyses revealed marked interpatient variability, with SN38 being more potent than 5-fluorouracil and

Skip to content The CRC Digest ♥ LIVING WITH CRC Study Examines Attachment Style, Symptom Distress, and Depression in CRC Survivors A cross-sectional study of 90 colorectal cancer survivors who completed treatment within the past three months explored relationships among adult attachment styles, symptom distress, and depressive symptoms, and whether mindfulness