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Whole genome sequencing-based ctDNA assay detects molecular residual disease across solid tumors

Skip to content The CRC Digest ◇ RESEARCH Whole genome sequencing-based ctDNA assay detects molecular residual disease across solid tumors In a pan-cancer cohort including colorectal cancer patients, those with ctDNA-positive molecular residual disease at 3 months post-surgery had significantly shorter recurrence-free survival (HR 23.7) compared to ctDNA-negative patients, and

Colorectal neoplasia detected at young age in Li-Fraumeni syndrome surveillance

Skip to content The CRC Digest ▪ SCREENING Colorectal neoplasia detected at young age in Li-Fraumeni syndrome surveillance In seven women with Li-Fraumeni syndrome, colorectal neoplasia was detected in five patients at a median age of 32.5 years, including one colorectal cancer at age 32 and three advanced adenomas; four

Serrated polyp detection rate may predict post-colonoscopy colorectal cancer beyond adenoma detection alone

Skip to content The CRC Digest ▪ SCREENING Serrated polyp detection rate may predict post-colonoscopy colorectal cancer beyond adenoma detection alone Among endoscopists with high adenoma detection rates, those with higher proximal serrated polyp detection rates (≥10%) had lower 5-year post-colonoscopy colorectal cancer incidence (0.06%) compared to those with lower

CRC Research Update — October 16, 2026

Today's colorectal cancer research highlights

Treatment Sequencing After Immunotherapy Progression in MSI-H/dMMR Disease

Skip to content The CRC Digest Treatment Sequencing After Immunotherapy Progression in MSI-H/dMMR Disease A clinical review proposes an evidence-informed framework for managing progression after immune checkpoint blockade in MSI-H/dMMR metastatic CRC, noting that BRAF V600E is common but not an absolute predictor of immunotherapy failure. (Journal of

Non-Aspirin NSAIDs Associated with Lower Adenoma Detection

Skip to content The CRC Digest Non-Aspirin NSAIDs Associated with Lower Adenoma Detection Among 64,889 Norwegian screening participants, use of non-aspirin NSAIDs was associated with lower odds of adenomas and advanced adenomas, with stronger effects seen in long-term users. (Gastroenterology Reports) This content is informational only and does not

Younger Patients Show Higher TP53 and SMAD4 Mutations

Skip to content The CRC Digest Younger Patients Show Higher TP53 and SMAD4 Mutations Meta-analysis of 43 studies found early-onset CRC has higher TP53 and SMAD4 mutation frequencies and lower APC and KRAS mutations, highlighting distinct molecular pathways in younger adults. (Cancers) This content is informational only and does not

Czech National Screening Program Reports 50% Mortality Decline Over 25 Years

Skip to content The CRC Digest ▪ SCREENING Czech National Screening Program Reports 50% Mortality Decline Over 25 Years Age-standardized colorectal cancer mortality in the Czech Republic fell 50% between 1998–2000 and 2022–2024, coinciding with a national screening program that detected cancer in 16,575 of 653,825 preventive

RAS Mutation Status Remains Prognostic After Metastasectomy

Skip to content The CRC Digest ◇ RESEARCH RAS Mutation Status Remains Prognostic After Metastasectomy Among 290 Brazilian patients with stage IV colorectal cancer, RAS wild-type status was independently associated with improved survival even in the subset who underwent metastasectomy, suggesting tumor biology continues to influence outcomes after surgical resection. (Cancers)

Liquid Biopsy Retesting May Predict Benefit from Anti-EGFR Rechallenge

Skip to content The CRC Digest ▸ TREATMENT Liquid Biopsy Retesting May Predict Benefit from Anti-EGFR Rechallenge (Neoplasma) This content is informational only and does not constitute medical advice. Always consult your oncologist or care team. © 2026 The CRC Digest — crcdigest.com