Sign in Subscribe

crc-research

A collection of 154 issues

Serrated lesions and colorectal cancers

Skip to content The CRC Digest Serrated lesions and colorectal cancers A review highlights that sessile serrated lesions contribute disproportionately to right-sided interval cancers, with limited evidence guiding best practices for resection and surveillance. (Dig Endosc) This content is informational only and does not constitute medical advice. Always consult your

CRC Research Finding

Skip to content The CRC Digest ◇ Left-sided and right-sided colorectal cancers show distinct molecular drivers Multi-omics analysis of 80 CRC patients revealed that left-sided tumors are predominantly driven by chromosomal instability, while right-sided cancers are primarily linked to microsatellite instability. (MedComm) This content is informational only and does not constitute

CRC Research Update — June 09, 2026

Today's colorectal cancer research highlights

CRC Research Finding

Skip to content The CRC Digest ◇ Single-cell analysis identifies epithelial cell fate signature predicting liver metastasis risk Researchers integrated single-cell RNA sequencing of paired liver metastasis tissues to define an epithelial cell fate gene signature, then projected it onto 433 primary CRC cases to establish a predictive model for liver

CRC Research Update — June 07, 2026

Today's colorectal cancer research highlights

CRC Research Finding

Skip to content The CRC Digest ♥ Review identifies gaps in measuring patient experience during surveillance colonoscopy A scoping review found no standard set of patient-reported outcomes or measures for individuals undergoing regular surveillance colonoscopy, despite guidelines recommending these assessments as quality indicators. (Quality of Life Research) This content is informational

CRC Research Update — June 06, 2026

Today's colorectal cancer research highlights

Novel SOS1 Inhibitors Show Potent Activity Against KRAS-Driven CRC

Skip to content The CRC Digest Novel SOS1 Inhibitors Show Potent Activity Against KRAS-Driven CRC Highly potent and selective SOS1 inhibitors disrupted the SOS1-KRAS interaction, inhibited nucleotide exchange in wild-type and multiple KRAS variants, and showed submicromolar anti-proliferative activity in colorectal cancer cells. (J Med Chem) This content is informational

Young-Onset Rectal Cancer Projected to Reach 25% of Cases by 2030

Skip to content The CRC Digest Young-Onset Rectal Cancer Projected to Reach 25% of Cases by 2030 Young-onset rectal cancer in adults under 50 is increasing worldwide and projected to represent up to 25% of rectal cancers by 2030, according to a tertiary center analysis. (Eur J Surg Oncol) This

Early-Onset CRC Represents Nearly 30% of Cases in Saudi Arabia

Skip to content The CRC Digest Early-Onset CRC Represents Nearly 30% of Cases in Saudi Arabia Of 1,365 patients with confirmed CRC, 406 (29.7%) had early-onset CRC (diagnosed before age 50), highlighting the growing burden of colorectal cancer in younger adults. (Saudi J Gastroenterol) This content is informational