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crc-research

A collection of 943 issues

Early-onset CRC shows distinct immune landscape

Skip to content The CRC Digest ♥ LIVING WITH CRC Early-onset CRC shows distinct immune landscape A review in Cancer Immunology Research synthesizes evidence on the tumor-immune microenvironment of colorectal cancer diagnosed before age 50, highlighting differences in immune composition, functional states, and spatial organization that may inform prevention strategies and

Liquid biopsy detects residual disease after oligometastasis surgery

Skip to content The CRC Digest ▪ SCREENING Liquid biopsy detects residual disease after oligometastasis surgery A prospective multicenter study of 118 patients with resectable colorectal oligometastases found that combining pretreatment circulating tumor DNA genomic profiling with post-operative molecular residual disease (MRD) detection identified patients at highest risk of recurrence, with

CRC Research Update — October 28, 2026

Today's colorectal cancer research highlights

WRN helicase emerges as therapeutic target in MSI-H colorectal cancer

Skip to content The CRC Digest WRN helicase emerges as therapeutic target in MSI-H colorectal cancer MSI-H and mismatch repair-deficient cancers show dependence on Werner syndrome RecQ helicase (WRN), a synthetic-lethal vulnerability linked to expanded TA-dinucleotide repeats and replication-associated genome instability, though dependency is not universal among all MSI-H tumors.

Elevated troponin before chemotherapy predicts cardiovascular events during treatment

Skip to content The CRC Digest ♥ LIVING WITH CRC Elevated troponin before chemotherapy predicts cardiovascular events during treatment Among 180 colorectal cancer patients starting 5-fluorouracil-based chemotherapy, baseline high-sensitivity troponin T above 14 ng/L was independently associated with major cardiovascular events, with more than half occurring within the first two

Inflammation-nutrition score predicts response to neoadjuvant therapy in rectal cancer

Skip to content The CRC Digest ▸ TREATMENT Inflammation-nutrition score predicts response to neoadjuvant therapy in rectal cancer In 312 patients with locally advanced rectal cancer, a low pretreatment inflammation-nutrition prognostic score (INPS) was independently associated with higher response rates (61% vs. 29%) and pathological complete response (39% vs. 12%), outperforming

Multiple intratumoral bacteria show stronger association with colorectal cancer than single species

Skip to content The CRC Digest ◇ RESEARCH Multiple intratumoral bacteria show stronger association with colorectal cancer than single species A Vietnamese cohort study found that co-detection of three bacterial species (F. nucleatum, A. muciniphila, and eae+ E. coli) was associated with a 21-fold increased odds of colorectal cancer compared to

Blood-based Shield test detects 83% of colorectal cancers but only 13% of advanced precancerous lesions

Skip to content The CRC Digest ▪ SCREENING Blood-based Shield test detects 83% of colorectal cancers but only 13% of advanced precancerous lesions In the large-scale ECLIPSE study of average-risk individuals, the Shield cell-free DNA assay showed 83.1% sensitivity for colorectal cancer but only 13.2% sensitivity for advanced precancerous

CRC Research Update — October 27, 2026

Today's colorectal cancer research highlights

Rural residents more likely to pay full cost of colonoscopy

Skip to content The CRC Digest Rural residents more likely to pay full cost of colonoscopy A national survey found 4.12% of rural residents reported paying all colonoscopy costs versus 3.01% of urban residents, with uninsured status and Hispanic ethnicity also associated with higher out-of-pocket spending. (Journal of