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preclinical

A collection of 63 issues

KRAS and BRAF mutations drive distinct chromatin and transcriptional programs

Skip to content The CRC Digest KRAS and BRAF mutations drive distinct chromatin and transcriptional programs Isogenic cell models revealed that RAS pathway mutations reconfigure chromatin accessibility and modulate WNT signaling, with elevated TCF7L2 expression in BRAF-mutant tumors independently predicting worse overall survival. (Cell Commun Signal) This content is informational

FGFR inhibition enhances immune checkpoint blockade in preclinical models

Skip to content The CRC Digest ◇ RESEARCH FGFR inhibition enhances immune checkpoint blockade in preclinical models Combining FGFR pathway inhibition with PD-1 blockade reduced T cell exhaustion and promoted antitumor macrophage activity in microsatellite stable colorectal cancer models, with TCGA data showing high FGFR3 expression correlates with worse prognosis. (BMC

Review maps immune resistance mechanisms in microsatellite-stable CRC

Skip to content The CRC Digest ◇ RESEARCH Review maps immune resistance mechanisms in microsatellite-stable CRC A comprehensive review details how microsatellite-stable colorectal cancer, which accounts for approximately 85% of all CRC cases, exhibits limited responsiveness to immune checkpoint inhibitors through multiple mechanisms including low tumor mutational burden, WNT/β-catenin pathway

P-selectin glycoprotein ligand-1 may link early- and late-onset colorectal cancer pathways

Skip to content The CRC Digest ◇ RESEARCH P-selectin glycoprotein ligand-1 may link early- and late-onset colorectal cancer pathways A review proposes that PSGL-1, a molecule involved in chronic gut inflammation, may function as a molecular bridge between early-onset and late-onset colorectal cancer, offering insight into shared pathophysiological mechanisms. (Biomed Pharmacother)

Chinese herbal formulation may shift pMMR tumors toward dMMR-like phenotype

Skip to content The CRC Digest ◇ RESEARCH Chinese herbal formulation may shift pMMR tumors toward dMMR-like phenotype Preclinical research using mouse models found that Xian-Lian-Jie-Du decoction (XLJDD) may modulate proficient mismatch repair (pMMR) colorectal tumors toward a dMMR-like phenotype, potentially enhancing responsiveness to anti-PD-1 therapy. (Phytomedicine) This content is informational

ENOPH1 identified as key mediator of KRAS G12D/G13D-driven metabolic reprogramming

Skip to content The CRC Digest ◇ RESEARCH ENOPH1 identified as key mediator of KRAS G12D/G13D-driven metabolic reprogramming Preclinical research shows ENOPH1 is upregulated by the KRAS-MEK-ERK pathway and sustains oncogenic TGF-β/SMAD signaling, representing a potential therapeutic target in KRAS-mutant colorectal cancer. (International Immunopharmacology) This content is informational only

Blocking PLA1A enzyme may enhance chemoimmunotherapy by reducing immunosuppressive macrophages

Skip to content The CRC Digest ◇ RESEARCH Blocking PLA1A enzyme may enhance chemoimmunotherapy by reducing immunosuppressive macrophages Single-cell RNA sequencing of paired samples before and after neoadjuvant chemotherapy revealed that non-responders had increased M2-like macrophage infiltration linked to elevated PLA1A. (Cancer Res) This content is informational only and does not

SPP1+ macrophages linked to chemotherapy resistance in colorectal liver metastasis

Skip to content The CRC Digest ◇ RESEARCH SPP1+ macrophages linked to chemotherapy resistance in colorectal liver metastasis Single-cell RNA sequencing identified a macrophage subpopulation marked by elevated SPP1 expression that is significantly enriched in patients who respond insufficiently to neoadjuvant chemotherapy; these cells suppress CD8+ T cell function through the

Propionate enhances CD8+ T-cell infiltration and immunotherapy response in preclinical models

Skip to content The CRC Digest ◇ RESEARCH Propionate enhances CD8+ T-cell infiltration and immunotherapy response in preclinical models A study using syngeneic MSI-H and MSS murine colorectal cancer models found that propionate, a short-chain fatty acid produced by gut microbiota, promoted CD8+ T-cell infiltration and enhanced efficacy when combined with

Gut Microbial Metabolites Screened for Role in Modulating PD-1/SHP-2 Interaction in MSS CRC

Skip to content The CRC Digest Gut Microbial Metabolites Screened for Role in Modulating PD-1/SHP-2 Interaction in MSS CRC Researchers established a screening system to identify gut microbiome-derived metabolites that may regulate anti-tumor immunity in microsatellite-stable colorectal cancer by modulating the PD-1/SHP-2 signaling pathway. (Journal for ImmunoTherapy of