13 May 2026

CRC Research Update — May 13, 2026

Creator: The CRC Digest
Published: 2026-05-13T13:40:09Z

Today's colorectal cancer research highlights

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IMPORTANT: The CRC Digest curates and summarizes publicly available research for informational and educational purposes only. Nothing in this newsletter constitutes medical advice, diagnosis, or treatment recommendation. The information provided should not be used as a substitute for professional medical advice. Always seek the guidance of your physician or other qualified health provider with any questions regarding a medical condition or treatment. Content is generated with AI assistance and reviewed by the editorial team. We are not medical professionals. Individual results, treatments, and outcomes vary.

Signal Key

TRIAL DATA clinical trial results, efficacy data, survival endpoints TREATMENT new treatment options, regimen changes, combination therapies REGULATORY FDA/EMA approvals, guideline updates, NCCN/ESMO changes RESEARCH cancer biology, biomarker discoveries, resistance pathways SCREENING screening, colonoscopy guidelines, liquid biopsy, molecular profiling LIVING WITH CRC survivorship, quality of life, side effects, patient decision-making, caregiver support

CRC Research Update

Split-Dose Irinotecan Shows Promise When Tailored to UGT1A1 Genotype
(Cancers)
AI Model Predicts Polyp Recurrence to Guide Surveillance Timing
Researchers developed a multimodal AI model using endoscopic images and clinical data from the ERCPMP-v5 dataset to predict post-polypectomy polyp recurrence, aiming to personalize colonoscopy surveillance intervals and reduce unnecessary procedures. (J Clin Med)
GDF15 Protein Linked to Chemotherapy Resistance in Colorectal Cancer
Lab studies identified GDF15 as a key molecule driving resistance to 5-fluorouracil and oxaliplatin by promoting stem cell-like properties in colorectal cancer cells; high GDF15 expression in liver metastasis specimens was associated with early recurrence and poor prognosis. (British Journal of Cancer)

🔎 Screening Watch

Advances in early detection and prevention

Liquid Biopsy and AI: A Comprehensive Review
A comprehensive review outlines how artificial intelligence and machine learning are transforming liquid biopsy analysis of circulating tumor DNA, CTCs, and exosomes for non-invasive colorectal cancer profiling. (Int J Mol Sci)

🧬 Biomarker Spotlight

Research by genetic subtype

BRAF and MMR Status Affect Staging Accuracy
A study of 754 stage II-III colorectal cancer patients found that concordance between preoperative and postoperative staging varied by molecular subtype, with BRAF-mutant and MMR-deficient tumors showing different patterns of staging discrepancies. (J Anus Rectum Colon)
Synchronous Tumors Can Have Different MMR Status
A case report describes a rare instance of synchronous ascending colon and rectal cancers with discordant mismatch repair status, highlighting the importance of lesion-specific molecular profiling for individualized treatment. (Front Oncol)

Stay informed as research continues to refine treatment strategies and improve outcomes for the colorectal cancer community.

CRC Research Update

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