29 Jun 2026

CRC Research Update — June 29, 2026

Creator: The CRC Digest
Published: 2026-06-29T16:39:11Z

Today's colorectal cancer research highlights

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IMPORTANT: The CRC Digest curates and summarizes publicly available research for informational and educational purposes only. Nothing in this newsletter constitutes medical advice, diagnosis, or treatment recommendation. The information provided should not be used as a substitute for professional medical advice. Always seek the guidance of your physician or other qualified health provider with any questions regarding a medical condition or treatment. Content is generated with AI assistance and reviewed by the editorial team. We are not medical professionals. Individual results, treatments, and outcomes vary.

Signal Key

TRIAL DATA clinical trial results, efficacy data, survival endpoints TREATMENT new treatment options, regimen changes, combination therapies REGULATORY FDA/EMA approvals, guideline updates, NCCN/ESMO changes RESEARCH cancer biology, biomarker discoveries, resistance pathways SCREENING screening, colonoscopy guidelines, liquid biopsy, molecular profiling LIVING WITH CRC survivorship, quality of life, side effects, patient decision-making, caregiver support

CRC Research Update

FDA-Approved RNA-Based At-Home Colorectal Cancer Screening Test Now Available Nationwide
Labcorp announced nationwide availability of ColoSense, the first FDA-approved RNA-based at-home colorectal cancer screening test. (StreetInsider)
Computer-Aided Detection Improves Adenoma Detection in Surveillance Colonoscopy
A population-based randomized trial of 5,309 patients in the Galician colorectal cancer screening program found that computer-aided detection (CADe) increased adenoma detection rate during post-polypectomy surveillance colonoscopy compared to standard high-definition colonoscopy. (Endoscopy)
Exelixis Updates Phase 3 Trial of Zanzalintinib Plus Immunotherapy in Metastatic CRC
Exelixis provided an update on the Phase 3 STELLAR-303 trial evaluating zanzalintinib in combination with an immune checkpoint inhibitor in patients with metastatic colorectal cancer. (BioSpace)
Real-World Study Identifies What Matters Most to Patients After CRC Treatment
A pragmatic observational study using patient-reported outcome measures (PROMs) following colorectal cancer treatment found that older patients reported better overall functional outcomes, while tumour site did not influence functional or symptom scores. (ANZ J Surg)

🔎 Screening Watch

Screening guidelines, early detection, and prevention advances

ColoSense RNA-Based At-Home Test
First FDA-approved RNA-based at-home screening test now available nationwide through Labcorp.
AI Detection in Surveillance Colonoscopy
Computer-aided detection increased adenoma detection in 5,309 patients undergoing post-polypectomy surveillance.

💙 Living with CRC

Survivorship, quality of life, and supportive care

Patient-Reported Outcomes After Treatment
Real-world study found older patients reported better functional outcomes, with age showing selective effects on quality of life measures.

Advances in screening technology and surveillance continue to improve early detection and patient outcomes.

CRC Research Update

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